about
NICDPre-NOTCHNOTCH2NOTCH2 [plasma membrane]Fringe-modified NOTCH2NOTCH2 fragment:DLL/JAGNOTCH2 Coactivator ComplexNOTCH2 mRNA translation controlled by miRNAsNOTCH2-ligand complex is cleaved to produce NEXT2NEXT2 is cleaved to produce NICD2NICD2 traffics to the nucleusGamma-secretase cleaves CNTN1:NOTCH2 to release NICD2NICD2 binds RBPJ and MAML in the nucleus
P527
P688
Notch signaling induces cell cycle arrest in small cell lung cancer cellsNotch2 protein distribution in human teeth under normal and pathological conditionsNOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathwayMutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone lossTruncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosisExpression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cellIntracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membraneHuman homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteinsC8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signallingMidkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.
P921
Q50257903-3ED651C7-427F-412E-892F-8354F767B0B5Q50273248-9BE3ABC9-E5C8-47C2-80AD-9216D52B1CA6Q50273255-CE498D7A-D180-4823-B77E-6F9CB7CA1388Q50273275-3508DA4F-5E59-4F1F-94CA-7550CFE29E40Q50273342-C3793A4C-B29B-4B87-81A1-C10D127E1232Q50273352-1790AEA4-5955-451A-A8B5-4DCF35349C22Q50273360-FCDC1631-B1CE-4F39-B0CB-D081D0D972FDQ50298604-C79DE72D-DA5B-4279-8A2C-FFF6958A25CBQ50298664-80EF83DB-D899-454D-B9B5-D6B875CF8BBCQ50298665-6A6F713B-CC05-4C67-A125-2FF55CDC2327Q50298665-ACBFB4FC-DC29-437D-8278-C274061C7260Q50298666-5C26082A-97EF-4769-8464-9315C91F6C56Q50298666-A70FB398-77EA-4FAD-A59B-0A472462EA48Q50298668-C392C686-0779-4036-A349-229A36E084C1Q50298670-557EF783-6AED-4E6C-A96E-6235463033EF
P527
Q24291129-44C20653-9A5B-486C-B687-D653B263523BQ24292753-EC98CE7E-40DC-4EBB-A9CE-032B4955E92CQ24293498-D262247A-C2C0-486E-A01B-AFBF2B92BBBFQ24295008-58D7AA16-15CB-4FC3-98D0-DA28145E78DCQ24295035-F927F493-0410-48F9-90E1-9BCC6EC1584CQ24302207-BF70F890-9007-49AB-B8C3-E974A04F9561Q24321237-B7A6ABE3-C2E6-42E4-88A1-F7F977949806Q24324093-676131E3-04A1-415D-B881-D389E841C504Q24337647-F494BCC4-53E9-4E2D-922F-EFBC1CF50DD1Q38291117-13C91C7C-6ABD-4923-8D2D-FE5CEA390ED0Q47391362-17EB3BF2-2F81-429B-883F-5CC256199EEDQ50062976-D8AC605F-0B8F-43DE-AB9C-F532F199A106
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Notch 2
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Notch receptor 2
@en
Notch receptor 2
@nl
type
label
Notch receptor 2
@en
Notch receptor 2
@nl
altLabel
NOTCH2
@en
Notch homolog 2
@en
neurogenic locus notch homolog protein 2
@en
notch 2
@en
prefLabel
Notch receptor 2
@en
Notch receptor 2
@nl
P361
P527
P680
P681
P682
P705
P352
P486
P638
P31
P352
P361
P486
P527
P637
NP_001186930
P681
P682
P702
P703
P705
ENSP00000256646
ENSP00000473427
ENSP00000477065
ENSP00000492223