Proprotein convertase subtilisin/kexin type 9

Proprotein convertase subtilisin/kexin type 9

Item
http://www.wikidata.org/entity/Q21130010
PCSK9
P688
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationAnnexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationDegradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularlyThe proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsFunctional characterization of Narc 1, a novel proteinase related to proteinase KHepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1cThe proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradationThe cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLRSelf-association of human PCSK9 correlates with its LDLR-degrading activityProapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinaseSecreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceRegulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levelsProprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptorA novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol
P921

Proprotein convertase subtilisin/kexin type 9

Item
http://www.wikidata.org/entity/Q21130010
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
proteiini
@fi
protein
@id
proteinë
@sq
proteïne in Proprotein convertase subtilisin/kexin type 9
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
PCSK9
@ar
PCSK9
@de
PCSK9
@es
PCSK9
@fi
PCSK9
@fr
PCSK9
@it
PCSK9
@ru
PCSK9
@uk
Proprotein convertase subtilisin/kexin type 9
@en
type
label
PCSK9
@ar
PCSK9
@de
PCSK9
@es
PCSK9
@fi
PCSK9
@fr
PCSK9
@it
PCSK9
@ru
PCSK9
@uk
Proprotein convertase subtilisin/kexin type 9
@en
altLabel
NARC-1
@en
Neural apoptosis-regulated convertase 1
@en
PC9
@en
PCSK9
@en
Proprotein convertase 9
@en
convertase subtilisin/kexin type 9 preproprotein
@en
neural apoptosis regulated convertase 1
@en
proprotein convertase subtilisin/kexin type 9
@en
subtilisin/kexin-like protease PC9
@en
prefLabel
PCSK9
@ar
PCSK9
@de
PCSK9
@es
PCSK9
@fi
PCSK9
@fr
PCSK9
@it
PCSK9
@ru
PCSK9
@uk
Proprotein convertase subtilisin/kexin type 9
@en
P31
P352
P361
P486
P527
P6366
P637
P638
P680
P681
P682
P702
P703
P705
P352
P486
P6366
P637
P638
P31
P352
P361
P486
P527
P6366
P637
P638
P680
P681
P682
P702
P703
P705