The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A
about
Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal EffectsMechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray CrystallographyBiochemical and Immunological Characterization of Truncated Fragments of the Receptor-Binding Domains of C. difficile Toxin AHigh temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxinsFrizzled proteins are colonic epithelial receptors for C. difficile toxin B.An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivoA novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore.The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection.Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB.Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B.Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.Clostridium difficile toxins: mediators of inflammation.Toward a structural understanding of Clostridium difficile toxins A and B.Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent EndocytosisDifference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470.Identification of an Essential Region for Translocation of Clostridium difficile Toxin B.Bacterial glycosyltransferase toxins.Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A Inhibitors.Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.Pyknotic cell death induced by Clostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity.Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.Amino Acid Differences in the 1753-to-1851 Region of TcdB Influence Variations in TcdB1 and TcdB2 Cell Entry.The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation.Evidence for dual receptor-binding sites in Clostridium difficile toxin A.Human neutrophils are activated by a peptide fragment of Clostridium difficile toxin B presumably via formyl peptide receptor.The role of toxins in Clostridium difficile infection.Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.Receptors and Binding Structures for Clostridium difficile Toxins A and B.The Conserved Cys-2232 in Toxin B Modulates Receptor Binding
P2860
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P2860
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A
description
2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@ast
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en-gb
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@nl
type
label
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@ast
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en-gb
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@nl
altLabel
The Repetitive Oligopeptide Se ...... Clostridium difficile Toxin A
@en
prefLabel
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@ast
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en-gb
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@nl
P2093
P2860
P3181
P1433
P1476
The repetitive oligopeptide se ...... Clostridium difficile toxin A
@en
P2093
Alexandra Olling
Florian Hoffmann
Helma Tatge
Ralf Gerhard
Sebastian Goy
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0017623
P407
P577
2011-01-01T00:00:00Z