Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
about
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.The endosomal-lysosomal system: from acidification and cargo sorting to neurodegenerationEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neuronsSASqPCR: robust and rapid analysis of RT-qPCR data in SASModeling the complex pathology of Alzheimer's disease in DrosophilaVCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFDThe role of mTOR signaling in Alzheimer diseaseAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's diseaseMechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagyMitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilizationLongevity pathways and memory agingTransgenic Drosophila models of Alzheimer's disease and tauopathiesReview: autophagy and neurodegeneration: survival at a cost?Robust RT-qPCR data normalization: validation and selection of internal reference genes during post-experimental data analysisAlzheimer's disease: diverse aspects of mitochondrial malfunctioning.Drosophila melanogaster in the study of human neurodegeneration.Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease.Deconvolution of the confounding variations for reverse transcription quantitative real-time polymerase chain reaction by separate analysis of biological replicate data.The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signalingInduction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficitsAge-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer's disease.Autophagy failure in Alzheimer's disease--locating the primary defect.p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis.Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson diseaseMesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cellsThe ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress.Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43Autophagy and neuronal cell death in neurological disordersDrosophila as a model system to study autophagy.Probing mechanisms that underlie human neurodegenerative diseases in DrosophilaIntraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity.
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P2860
Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@ast
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en-gb
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@nl
type
label
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@ast
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en-gb
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@nl
prefLabel
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@ast
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en-gb
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@nl
P2093
P2860
P3181
P1433
P1476
Abeta42-induced neurodegenerat ...... lysosomal injury in Drosophila
@en
P2093
Daijun Ling
Ho-Juhn Song
Paul M Salvaterra
Thomas P Neufeld
P2860
P3181
P356
10.1371/JOURNAL.PONE.0004201
P407
P577
2009-01-01T00:00:00Z