Signal-regulated activation of serum response factor is mediated by changes in actin dynamicsIsolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response elementG-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assemblyAn actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-AMapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectivelyMolecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MALCharacterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response elementSpatial flexibility in ternary complexes between SRF and its accessory proteinsStructure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivatorStructures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativityThe POZ domain: a conserved protein-protein interaction motifAnalysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRFThe essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signalingActin dynamics control SRF activity by regulation of its coactivator MALHuman SRF-related proteins: DNA-binding properties and potential regulatory targets.Regulation of transcription by MAP kinase cascadesLocal delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.Regulation of SRF activity by Rho family GTPases.Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity.Isolation and characterization of SRF accessory proteins.Growth factors and gene expression: fresh insights from arrays.Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis.Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.Actin' together: serum response factor, its cofactors and the link to signal transduction.cis and trans activation of globin gene transcription in transient assays.The SRE: a growth factor responsive transcriptional regulator.The role of the MRTF-A/SRF pathway in ocular fibrosis.DNA binding specificity determinants in MADS-box transcription factors.SRF and MCM1 have related but distinct DNA binding specificities.A sensitive method for the determination of protein-DNA binding specificities.Journey to the surface of the cell: Fos regulation and the SRE.SRF Co-factors Control the Balance between Cell Proliferation and Contractility.Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization.Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor.
P50
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P50
description
Research Director at The Francis Crick Institute in London
@en
britischer Molekularbiologe und Biochemiker
@de
scheikundige
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name
Richard Henry Treisman
@fr
Richard Henry Treisman
@nl
Richard Henry Treisman
@sl
Richard Treisman
@de
Richard Treisman
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Richard Treisman
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type
label
Richard Henry Treisman
@fr
Richard Henry Treisman
@nl
Richard Henry Treisman
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Richard Treisman
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Richard Treisman
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Richard Treisman
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altLabel
Richard H. Treisman
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Richard Henry Treisman
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Richard Treisman
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prefLabel
Richard Henry Treisman
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Richard Henry Treisman
@nl
Richard Henry Treisman
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Richard Treisman
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Richard Treisman
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Richard Treisman
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7004579369
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P2070
richard-treisman-12432
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P214
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no99085442
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0000-0002-9658-0067
P5463
Treisman_Richard
P569
1954-10-07T00:00:00Z
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lccn-no99085442