Triggering receptor expressed on myeloid cells 2

Triggering receptor expressed on myeloid cells 2

Item
http://www.wikidata.org/entity/Q21173956
TREM2
P688
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytesDAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic featuresNeurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanismsRare TREM2 variants associated with Alzheimer's disease display reduced cell surface expressionTREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.FRMD4A-cytohesin signaling modulates the cellular release of tau.
P921

Triggering receptor expressed on myeloid cells 2

Item
http://www.wikidata.org/entity/Q21173956
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Triggering receptor expressed on myeloid cells 2
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Triggering receptor expressed on myeloid cells 2
@en
type
label
Triggering receptor expressed on myeloid cells 2
@en
altLabel
TREM2
@en
triggering receptor expressed on monocytes 2
@en
triggering receptor expressed on myeloid cells 2
@en
triggering receptor expressed on myeloid cells 2a
@en
prefLabel
Triggering receptor expressed on myeloid cells 2
@en
P31
P352
P361
P527
P637
P680
P681
P682
P702
P703
P705
P352
P637
P31
P352
P361
P527
P637
P680
P681
P682
P702
P703
P705