about
Centriole assembly and the role of Mps1: defensible or dispensable?Building a ninefold symmetrical barrel: structural dissections of centriole assemblyThe Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole DuplicationCommon variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryosSmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosisIdentification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation.Loss of KLF14 triggers centrosome amplification and tumorigenesis.Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domainMutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathyPolo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.The importance of a single primary cilium.Polo-like kinases: structural variations lead to multiple functions.A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain.Regulation of centriolar satellite integrity and its physiologyPolo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein.Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy.Mitotic Kinases and p53 Signaling.PLK4: a link between centriole biogenesis and cancer.Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma.PLK4 is essential for meiotic resumption in mouse oocytes.KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number.YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defectCell polarity: having and making sense of direction-on the evolutionary significance of the primary cilium/centrosome organ in Metazoa
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Polo-like kinase 4: the odd one out of the family
@ast
Polo-like kinase 4: the odd one out of the family
@en
Polo-like kinase 4: the odd one out of the family
@en-gb
Polo-like kinase 4: the odd one out of the family
@nl
type
label
Polo-like kinase 4: the odd one out of the family
@ast
Polo-like kinase 4: the odd one out of the family
@en
Polo-like kinase 4: the odd one out of the family
@en-gb
Polo-like kinase 4: the odd one out of the family
@nl
prefLabel
Polo-like kinase 4: the odd one out of the family
@ast
Polo-like kinase 4: the odd one out of the family
@en
Polo-like kinase 4: the odd one out of the family
@en-gb
Polo-like kinase 4: the odd one out of the family
@nl
P2860
P3181
P356
P1433
P1476
Polo-like kinase 4: the odd one out of the family
@en
P2093
James E Sillibourne
Michel Bornens
P2860
P2888
P3181
P356
10.1186/1747-1028-5-25
P407
P577
2010-01-01T00:00:00Z
P5875
P6179
1004690480