The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
about
Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptorCo-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cellsN-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin bindingHereditary hemochromatosis in the post-HFE eraNeogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membraneHaemochromatosisLocalization of iron transport and regulatory proteins in human cellsComparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFEIntestinal expression of genes involved in iron absorption in humansHemochromatosis gene in leukemia and lymphomaEffects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosisHeavy metal poisoning and cardiovascular diseaseGenetic susceptibility to lead poisoningTMEM14C is required for erythroid mitochondrial heme metabolismMitoferrin is essential for erythroid iron assimilationVariants in iron metabolism genes predict higher blood lead levels in young children.Metal ion transporters in mammals: structure, function and pathological implications.Characterization of the interaction between diferric transferrin and transferrin receptor 2 by functional assays and atomic force microscopy.Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.Ubiquitination of lysine-331 by Kaposi's sarcoma-associated herpesvirus protein K5 targets HFE for lysosomal degradationTraffic jam: a compendium of human diseases that affect intracellular transport processes.Biological and clinical aspects of soluble transferrin receptor.Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.The hemochromatosis protein HFE inhibits iron export from macrophages.Physiology of iron transport and the hemochromatosis gene.Molecular pathogenesis of iron overload.Molecular mechanisms and regulation of iron transport.Phlebotomy increases cadmium uptake in hemochromatosis.Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.An iron regulatory gene signature predicts outcome in breast cancer.Current and future therapy in haemochromatosis and Wilson's disease.Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosisLiver iron transportIron Imports. VI. HFE and regulation of intestinal iron absorption.The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis.
P2860
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P2860
The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@ast
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en-gb
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@nl
type
label
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@ast
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en-gb
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@nl
prefLabel
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@ast
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en-gb
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@nl
P2093
P2860
P356
P1476
The hereditary hemochromatosis ...... ated iron uptake in HeLa cells
@en
P2093
P2860
P304
P356
10.1074/JBC.274.13.9022
P407
P577
1999-03-26T00:00:00Z