Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats
about
Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indicationsArachidonic acid cytochrome P450 epoxygenase pathwayProtective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channelsPharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogsInhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive ratsFenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experienceBeneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse modelIntrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage.CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in obese mice.Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive ratsHigh salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels.Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease.Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion InjuryReduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency.Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage.Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice.Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy.Epoxyeicosatrienoic acids: formation, metabolism and potential role in tissue physiology and pathophysiology.Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease.Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.Modulation of cardiac cytochrome P450 in patients with heart failure.The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic DiseasesAgonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway.Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis.Orally Active Epoxyeicosatrienoic Acid Analogs.Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.
P2860
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P2860
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Increasing or stabilizing rena ...... and hypertension in obese rats
@ast
Increasing or stabilizing rena ...... and hypertension in obese rats
@en
Increasing or stabilizing rena ...... and hypertension in obese rats
@en-gb
Increasing or stabilizing rena ...... and hypertension in obese rats
@nl
type
label
Increasing or stabilizing rena ...... and hypertension in obese rats
@ast
Increasing or stabilizing rena ...... and hypertension in obese rats
@en
Increasing or stabilizing rena ...... and hypertension in obese rats
@en-gb
Increasing or stabilizing rena ...... and hypertension in obese rats
@nl
prefLabel
Increasing or stabilizing rena ...... and hypertension in obese rats
@ast
Increasing or stabilizing rena ...... and hypertension in obese rats
@en
Increasing or stabilizing rena ...... and hypertension in obese rats
@en-gb
Increasing or stabilizing rena ...... and hypertension in obese rats
@nl
P2093
P2860
P921
P1476
Increasing or stabilizing rena ...... and hypertension in obese rats
@en
P2093
Bruce D Hammock
Christophe Morisseau
JingFeng Wang
Mong-Heng Wang
Tianxin Yang
P2860
P2880
P304
P356
10.1152/AJPRENAL.00004.2007
P407
P577
2007-04-18T00:00:00Z