Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase
about
Functions of the Hsp90 chaperone system: lifting client proteins to new heightsThe human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopyDifferent Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug DesignA novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex.Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p)Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.Gambogic acid, a natural product inhibitor of Hsp90The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation.Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stressRegulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.Structure of an Hsp90-Cdc37-Cdk4 complex.Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitorsFatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.Cdc37 goes beyond Hsp90 and kinasesIdentification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).Phosphorylated and unphosphorylated serine 13 of CDC37 stabilize distinct interactions between its client and HSP90 binding domains.Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery.Chaperoning erythropoiesis.Characterization of celastrol to inhibit hsp90 and cdc37 interaction.Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignanciesA central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90.CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.Structural bioinformatics and protein docking analysis of the molecular chaperone-kinase interactions: towards allosteric inhibition of protein kinases by targeting the hsp90-cdc37 chaperone machinery.Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.Candida albicans Cdc37 interacts with the Crk1 kinase and is required for Crk1 production.
P2860
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P2860
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@ast
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en-gb
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@nl
type
label
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@ast
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en-gb
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@nl
prefLabel
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@ast
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en-gb
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@nl
P2093
P2860
P3181
P356
P1476
Hsp90 regulates p50(cdc37) fun ...... me-regulated eIF2 alpha kinase
@en
P2093
B T Scroggins
N Grammatikakis
S D Hartson
P2860
P304
P3181
P356
10.1074/JBC.M007583200
P407
P577
2001-01-05T00:00:00Z