MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
about
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promotersThe notch regulator MAML1 interacts with p53 and functions as a coactivatorAtaxin-1 and Brother of ataxin-1 are components of the Notch signalling pathwayMT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell developmentThe Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesisRITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene programSHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitrop300 acts as a transcriptional coactivator for mammalian Notch-1Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complexDirect inhibition of the NOTCH transcription factor complexThe ankyrin repeat as molecular architecture for protein recognitionThe Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexThe transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell developmentNotch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinasesMammary epithelial cell transformation: insights from cell culture and mouse models.Notch Signaling in Neuroendocrine TumorsTargeting the Notch signaling pathway in cancer therapeuticsFrom fly wings to targeted cancer therapies: a centennial for notch signalingProtein lysine acetylation by p300/CBPRAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription ComplexStructural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexesThe CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathwayPhosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathwaysStructural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complexAssociation of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of NotchIdentification of new human mastermind proteins defines a family that consists of positive regulators for notch signalingCross-regulation between Notch and p63 in keratinocyte commitment to differentiationAlcohol-induced histone acetylation reveals a gene network involved in alcohol toleranceCharacterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expressionDual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytesNotch directly regulates Gata3 expression during T helper 2 cell differentiationNotch signalling: a simple pathway becomes complexMastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts
P2860
Q24291301-1FF70DEA-C2D6-4C7F-8801-919F1A71624CQ24298020-471B7CA8-0FD1-46B1-84A6-93DEFAB94F05Q24299218-87B812C9-5D4D-4E86-8657-9D749A86C052Q24302346-0A30F2C7-63F0-4617-AE82-B6BDCA6B1BB0Q24306223-360B18FD-F488-4D99-BBF9-1669F6B0B5BEQ24308025-0E51C2ED-8499-459A-A800-6F7E1EF869F1Q24309682-2352F935-6FAF-4C0F-A908-649D1F7F83CFQ24311427-FB649E2D-DBAA-4C62-B760-A87EC1FB7BF9Q24534941-2203C645-72EA-41E3-8B65-1819D32199D1Q24537773-17BC2502-E529-421D-A79B-97CFB85EFDE4Q24548267-4A5AA9EB-136A-42BD-8EB6-3AB6A26B4957Q24550850-3C419D20-DD7C-4EA7-9E38-89E02C28C6CDQ24634015-77F1D017-8D82-45E2-902E-C61345C54E2BQ24646394-3331DC8B-4616-4646-BC85-F8109B1C4C15Q24670362-82395AC8-7089-44C7-BC6F-1BFA71ADD309Q24670708-8D7EAE57-D285-498D-86C9-7C96BCB31FAEQ24675233-412ED4E9-FBB1-46ED-B6BC-AD078981634CQ24678633-55BABDF6-BE3F-4A9C-AD33-493F6B5E884EQ24680631-8813B722-889E-46C6-9248-9A1C4060A254Q24810846-11FD4648-6B2B-47C1-AEA9-FB5D6ED1D14FQ26752380-C0C29297-5050-41B1-8364-B7CEC0BB3D52Q26863580-8AE8130B-E863-4BE6-A1D2-F6C4758E3F1FQ27004534-08AF4F39-0E4E-4C91-BECD-72BB1B9C1730Q27021749-0689C360-F776-4A69-8632-EAC85AAE59E8Q27650201-D91E454F-5CDE-48D7-8A83-4E2A51B2FDA3Q27665343-7931A466-E443-48F3-BE2F-30F445C38C01Q28072734-CE108D76-9B70-4FF1-A516-DEEFD6A10A14Q28177635-88629C80-96E9-49A1-BB15-368CA127CF76Q28184514-6D0CBA69-55F0-4E44-AAD1-FD9EE749177AQ28200963-D6C899AD-7280-48F2-BFC5-E641530DAC1BQ28208323-F7DFAA79-C15E-426E-873E-BC964821B95EQ28510156-A322DA8D-2AF8-4FF3-8998-073ACAF88590Q28536909-2B47C2E1-6C95-400A-A0FE-4DB29928804DQ28580975-6491E833-EEE5-4475-B4D7-CDF5C77B7CCFQ28592502-EE0FC402-E26D-4C2F-9617-1DC77EE70D71Q28593674-06F66FDB-AA05-47A0-8599-4411857B9DACQ28594834-32AE86C8-7CC3-44E7-885B-87F1BD3F88E3Q29555851-53BEDFAA-85F6-4779-B4CF-0CE66F2F7A24Q30366843-B9DD7A67-A8DA-4190-BD08-65E5B373DE12Q30416251-AD7B069C-D662-4921-B010-3A0B8BE835B5
P2860
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@ast
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en-gb
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@nl
type
label
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@ast
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en-gb
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@nl
prefLabel
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@ast
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en-gb
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@nl
P2093
P921
P3181
P356
P1433
P1476
MAML1, a human homologue of Dr ...... -activator for NOTCH receptors
@en
P2093
J D Griffin
S Artavanis-Tsakonas
S C Blacklow
P2888
P3181
P356
10.1038/82644
P407
P577
2000-12-01T00:00:00Z
P5875
P6179
1011642177