Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation
about
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac diseaseGetting the skinny on thick filament regulation in cardiac muscle biology and diseaseA public resource facilitating clinical use of genomesPhosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectivesMolecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutationsSystematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathyThe effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse heartsA mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillationA novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chainCardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivoThe significance of regulatory light chain phosphorylation in cardiac physiologyDiastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model miceIn the thick of it: HCM-causing mutations in myosin binding proteins of the thick filamentCitrullination of myofilament proteins in heart failure.In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosinHypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in miceMechanical defects of muscle fibers with myosin light chain mutants that cause cardiomyopathyCardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.Serum proteomic signature of human chagasic patients for the identification of novel potential protein biomarkers of disease.Signaling to myosin regulatory light chain in sarcomeresImpact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanicsA chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins.Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Novel familial dilated cardiomyopathy mutation in MYL2 affects the structure and function of myosin regulatory light chain.Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber.The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.A Novel Method of Determining the Functional Effects of a Minor Genetic Modification of a Protein.Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load.Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in diseaseMyosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filamentsMalignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice.Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kineticsA functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58QBroad-based molecular autopsy: a potential tool to investigate the involvement of subtle cardiac conditions in sudden unexpected death in infancy and early childhood.Pseudophosphorylation of cardiac myosin regulatory light chain: a promising new tool for treatment of cardiomyopathy.Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscle.Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle.
P2860
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P2860
Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@ast
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en-gb
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@nl
type
label
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@ast
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en-gb
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@nl
prefLabel
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@ast
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en-gb
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@nl
P2093
P2860
P921
P3181
P356
P1476
Familial hypertrophic cardiomy ...... + binding, and phosphorylation
@en
P2093
D Szczesna
J D Potter
P2860
P304
P3181
P356
10.1074/JBC.M009823200
P407
P577
2001-03-09T00:00:00Z