Association of human aging with a functional variant of klotho.
about
We are ageingRole of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.Hyperphosphatemia of chronic kidney diseaseSuppression of aging in mice by the hormone KlothoKlotho and agingAging syndrome genes and premature coronary artery diseaseKlotho in cardiovascular disease: Current and future perspectivesBiological Role of Anti-aging Protein KlothoSignificant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular diseaseKlotho, phosphate and inflammation/ageing in chronic kidney diseaseKlotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depressionFunctional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi originKlotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinomaKlotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivoN-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse modelsDisentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures.The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK CaucasiansKlotho in the cerebrospinal fluid of adults with and without Alzheimer's diseaseRhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice.Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan.FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts.KLOTHO allele status and the risk of early-onset occult coronary artery diseaseKlotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African AmericansLife extension factor klotho enhances cognition.Protective effect of klotho protein against cisplatin ototoxicity in an auditory cell line.Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.Between destiny and disease: genetics and molecular pathways of human central nervous system agingKlotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in miceKlotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.Implications of Klotho in vascular health and disease.Renal function and klotho gene polymorphisms among Uygur and Kazak populations in Xinjiang, China.Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease.Plasma klotho and mortality risk in older community-dwelling adults.Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature agingVariation in longevity gene KLOTHO is associated with greater cortical volumes.Molecular basis of Klotho: from gene to function in agingLack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort.Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho miceGenetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study.
P2860
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P2860
Association of human aging with a functional variant of klotho.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Association of human aging with a functional variant of klotho
@nl
Association of human aging with a functional variant of klotho.
@ast
Association of human aging with a functional variant of klotho.
@en
Association of human aging with a functional variant of klotho.
@en-gb
type
label
Association of human aging with a functional variant of klotho
@nl
Association of human aging with a functional variant of klotho.
@ast
Association of human aging with a functional variant of klotho.
@en
Association of human aging with a functional variant of klotho.
@en-gb
prefLabel
Association of human aging with a functional variant of klotho
@nl
Association of human aging with a functional variant of klotho.
@ast
Association of human aging with a functional variant of klotho.
@en
Association of human aging with a functional variant of klotho.
@en-gb
P2093
P2860
P3181
P356
P1476
Association of human aging with a functional variant of klotho.
@en
P2093
Albert Arking
Alice Krebsova
Dan E Arking
Harry C Dietz
I Saira Mian
Iain McIntosh
Linda Fried
Milan Macek
Srabani Dey
P2860
P304
P3181
P356
10.1073/PNAS.022484299
P407
P50
P577
2002-01-15T00:00:00Z