Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
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Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variantsInverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epitheliaReduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles BiogenesisBiosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidArachidonic acid metabolism in human prostate cancerDiscovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse librariesBiomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS.15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression.Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancerDownregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancerCyclooxygenases and lipoxygenases in cancer.Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.Oxidized LDL triggers pro-oncogenic signaling in human breast mammary epithelial cells partly via stimulation of MiR-2115-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma.Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis.The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8.Genetic variation in IL-16 miRNA target site and time to prostate cancer diagnosis in African-American men.Potency of non-steroidal anti-inflammatory drugs in chemotherapy.Industrial potential of lipoxygenases.Computer-aided (in silico) approaches in the mode-of-action analysis and safety assessment of ostarine and 4-methylamphetamine.Gamma tocopherol upregulates the expression of 15-S-HETE and induces growth arrest through a PPAR gamma-dependent mechanism in PC-3 human prostate cancer cells.Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer.Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy.An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis.Qualitative and Quantitative analysis of 3D predicted arachidonate 15-lipoxygenase-B (15-LOX-2) from Homo sapiens.Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells.Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked.Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate.Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.
P2860
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P2860
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@ast
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en-gb
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@nl
type
label
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@ast
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en-gb
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@nl
prefLabel
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@ast
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en-gb
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@nl
P2093
P2860
P921
P3181
P356
P1476
Evidence that arachidonate 15- ...... rmal prostate epithelial cells
@en
P2093
Bobby Bhatia
Carlos J Maldonado
Dean G Tang
Dharam Chopra
Haiyen E Zhau
Jeanine Traag
Jianjun Shen
Junwei Liu
Leland W K Chung
Peiying Yang
P2860
P304
P3181
P356
10.1074/JBC.M111936200
P407
P577
2002-05-03T00:00:00Z