Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
about
Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cellsMyocardin is sufficient for a smooth muscle-like contractile phenotypeSRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cellsPericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain agingInduction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotypeHypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental RelationshipImpaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1The pericyte: a forgotten cell type with important implications for Alzheimer's disease?A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysmReduction of circulating endothelial cells in peripheral blood of ALS patientsNeurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersGlial and neuronal control of brain blood flowThe smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial DopplerNox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease.Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies.Premature aging in skeletal muscle lacking serum response factor.Central nervous system pericytes in health and disease.Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cellsNeurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease.Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease.Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heartCerebral amyloid angiopathy in the elderlyImpaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease.Linking actin dynamics and gene transcription to drive cellular motile functions.The science of stroke: mechanisms in search of treatments.Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brainPhosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloidAPP knockout mice experience acute mortality as the result of ischemia.The overlap between neurodegenerative and vascular factors in the pathogenesis of dementiaP2Y receptors in Alzheimer's disease.Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.Serum response factor-dependent MicroRNAs regulate gastrointestinal smooth muscle cell phenotypesNeurovascular function in Alzheimer's disease patients and experimental models.Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective studyChanges in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunctionCharacterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseDelayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β.
P2860
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P2860
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Serum response factor and myoc ...... ation in Alzheimer's phenotype
@nl
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@ast
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en-gb
type
label
Serum response factor and myoc ...... ation in Alzheimer's phenotype
@nl
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@ast
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en-gb
prefLabel
Serum response factor and myoc ...... ation in Alzheimer's phenotype
@nl
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@ast
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en-gb
P2093
P2860
P921
P356
P1476
Serum response factor and myoc ...... tion in Alzheimer's phenotype.
@en
P2093
Andrew Brooks
Berislav V Zlokovic
Jeffrey W Streb
Jiyuan Chen
Joseph M Miano
Nienwen Chow
Rashid Deane
Robert D Bell
William Van Nostrand
P2860
P304
P356
10.1073/PNAS.0608251104
P407
P577
2007-01-10T00:00:00Z