NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
about
Connecting the Dots: From DNA Damage and Repair to AgingN-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsProtein methylation at the surface and buried deep: thinking outside the histone boxChromatin binding of RCC1 during mitosis is important for its nuclear localization in interphaseNovel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase.Molecular basis for histone N-terminal methylation by NRMT1A direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferasesFacile synthesis of SAM-peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromerePosttranslational modification of CENP-A influences the conformation of centromeric chromatin.Substrate specificity of mammalian N-terminal α-amino methyltransferase NRMTChromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells.α-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair.NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging.New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.Kinetic mechanism of protein N-terminal methyltransferase 1.Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesisCatalytic promiscuity of a bacterial α-N-methyltransferase.Structural basis for substrate recognition by the human N-terminal methyltransferase 1Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.Nucleosome functions in spindle assembly and nuclear envelope formation.Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA.Protein and nucleic acid methylating enzymes: mechanisms and regulationN-methylation of peptides and proteins: an important element for modulating biological functions.Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitorsDevelopmental regulation of N-terminal H2B methylation in Drosophila melanogasterPhosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity.Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1Gene sequencing and characterization of the light-harvesting complex 2 from thermophilic purple sulfur bacterium Thermochromatium tepidum.N-Terminal methylation of proteasome subunit Rpt1 in yeast.Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.The ribosome: A hot spot for the identification of new types of protein methyltransferases.An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
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NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein
@nl
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@ast
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en-gb
type
label
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein
@nl
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@ast
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en-gb
prefLabel
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein
@nl
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@ast
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en-gb
P2093
P2860
P50
P921
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P1433
P1476
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
@en
P2093
Christine E Schaner Tooley
Donald F Hunt
Ian G Macara
Michal Sabat
Tara L Muratore-Schroeder
P2860
P2888
P304
P3181
P356
10.1038/NATURE09343
P407
P577
2010-08-01T00:00:00Z
P5875
P6179
1014929459