Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
about
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperoneMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationMolecular mechanism of pancreatic and salivary gland fluid and HCO3 secretionAn in silico analysis of the binding modes and binding affinities of small molecule modulators of PDZ-peptide interactionsNHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and functionThe ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa.The L441P mutation of cystic fibrosis transmembrane conductance regulator and its molecular pathogenic mechanisms in a Korean patient with cystic fibrosis.Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains.Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.Physiology of epithelial chloride and fluid secretionSyntaxin 16 binds to cystic fibrosis transmembrane conductance regulator and regulates its membrane trafficking in epithelial cells.CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners.The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval.Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMPAnalysis of CFTR interactome in the macromolecular complexes.Structural basis for NHERF1 PDZ domain bindingA PDZ-Like Motif in the Biliary Transporter ABCB4 Interacts with the Scaffold Protein EBP50 and Regulates ABCB4 Cell Surface Expression.Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATPWhat can we learn about fertilization from cystic fibrosis?Nedd4-2 does not regulate wt-CFTR in human airway epithelial cellsTransepithelial bicarbonate secretion: lessons from the pancreasCholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins.Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock.Shank2 contributes to the apical retention and intracellular redistribution of NaPiIIa in OK cellsAnchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.Na⁺/H⁺ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney.Mis-trafficking of bicarbonate transporters: implications to human diseases.Plasticity of PDZ domains in ligand recognition and signaling.AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.Structural Dynamics of the Vimentin Coiled-coil Contact Regions Involved in Filament Assembly as Revealed by Hydrogen-Deuterium Exchange.BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction.Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice.Mechanistic insight into control of CFTR by AMPK.The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
P2860
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P2860
Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@ast
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en-gb
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@nl
type
label
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@ast
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en-gb
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@nl
prefLabel
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@ast
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en-gb
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@nl
P2093
P3181
P356
P1476
Dynamic regulation of cystic f ...... ractions of molecular adaptors
@en
P2093
Eunjoon Kim
Ji Hyun Lee
Kyung Hwan Kim
Marco Conti
Wan Namkung
P304
P3181
P356
10.1074/JBC.M610857200
P407
P577
2007-04-06T00:00:00Z