Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
about
Central role of the P2Y12 receptor in platelet activationInternational Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyStructure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysisP2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cellsStructure of the human P2Y12 receptor in complex with an antithrombotic drugDeterminants of the interindividual variability in response to antiplatelet drugsEvaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation?The P2Y 13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y 12 locus, is not associated with acute myocardial infarction.Qualitative disorders of platelets and megakaryocytes.Inherited platelet disorders: thrombocytopenias and thrombocytopathies.Inherited platelet disorders: a clinical approach to diagnosis and management.Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptor.Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin.Rare platelet GPCR variants: what can we learn?Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.New Developments in Platelet Cyclic Nucleotide Signalling: Therapeutic Implications.Single nucleotide polymorphism network: a combinatorial paradigm for risk prediction.Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.Clopidogrel: interactions with the P2Y12 receptor and clinical relevance.Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.GSK3beta is a negative regulator of platelet function and thrombosis.P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery diseaseA review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO.What's new in using platelet research? To unravel thrombopathies and other human disorders.Structural and functional evolution of the P2Y(12)-like receptor group.Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesisPlatelet physiology and antiplatelet agents.Platelet receptor signaling in thrombus formation.P2Y12 receptor in platelet activation.P2Y12 receptor: platelet thrombus formation and medical interventions.Molecular mechanisms of platelet P2Y(12) receptor regulation.Molecular defects of the platelet P2 receptors.Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation.Platelet-related biomarkers and their response to inhibition with aspirin and p2y12-receptor antagonists in patients with acute coronary syndrome.Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.P2Y12 receptors in primary microglia activate nuclear factor of activated T-cell signaling to induce C-C chemokine 3 expression.A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding.An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets.The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.Clopidogrel resistance: fact and fiction.
P2860
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P2860
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Molecular bases of defective s ...... tient with congenital bleeding
@ast
Molecular bases of defective s ...... tient with congenital bleeding
@en
Molecular bases of defective s ...... tient with congenital bleeding
@en-gb
Molecular bases of defective s ...... tient with congenital bleeding
@nl
type
label
Molecular bases of defective s ...... tient with congenital bleeding
@ast
Molecular bases of defective s ...... tient with congenital bleeding
@en
Molecular bases of defective s ...... tient with congenital bleeding
@en-gb
Molecular bases of defective s ...... tient with congenital bleeding
@nl
prefLabel
Molecular bases of defective s ...... tient with congenital bleeding
@ast
Molecular bases of defective s ...... tient with congenital bleeding
@en
Molecular bases of defective s ...... tient with congenital bleeding
@en-gb
Molecular bases of defective s ...... tient with congenital bleeding
@nl
P2093
P2860
P921
P356
P1476
Molecular bases of defective s ...... tient with congenital bleeding
@en
P2093
Anna Lecchi
Constantino Martinez
Jerry Ware
Maddalena L Zighetti
Pamela B Conley
Rossana Lombardi
Zaverio M Ruggeri
P2860
P304
P356
10.1073/PNAS.0437879100
P407
P577
2003-02-10T00:00:00Z