Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
about
Digested disorder: Quarterly intrinsic disorder digest (January/February/March, 2013).Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle controlKnockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machineryRSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferationPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsMechanism of p27 Unfolding for CDK2 Reactivation.Role of T198 modification in the regulation of p27(Kip1) protein stability and functionTargeting CDK4 and CDK6: From Discovery to TherapyBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction pointThe selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiationCommon and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse modelA decade and a half of protein intrinsic disorder: biology still waits for physicsCell signaling, post-translational protein modifications and NMR spectroscopyThe unfoldomics decade: an update on intrinsically disordered proteins.Understanding protein non-folding.Reciprocal regulation of metabolic and signaling pathways.Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumoursContact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent mannerInhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cellsRapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1.Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation.Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesThe role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cellsThe protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21Expanding the proteome: disordered and alternatively folded proteins.Dasatinib induces autophagic cell death in human ovarian cancer.TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagyDasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cellsEstrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.Probing the role of nascent helicity in p27 function as a cell cycle regulator.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.
P2860
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P2860
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@ast
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en-gb
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@nl
type
label
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@ast
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en-gb
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@nl
prefLabel
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@ast
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en-gb
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@nl
P2093
P3181
P1433
P1476
Cdk-inhibitory activity and st ...... by oncogenic tyrosine kinases
@en
P2093
Eva-Maria Keidel
Heidelinde Jäkel
Ludger Hengst
M Brett Waddell
Matthias Grimmler
Michael Kullmann
Richard W Kriwacki
Thomas Mund
Yuefeng Wang
Zoran Cilensek
P304
P3181
P356
10.1016/J.CELL.2006.11.047
P407
P577
2007-01-26T00:00:00Z