Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
about
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseStructures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategyPrivileged diazepine compounds and their emergence as bromodomain inhibitors.Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected]Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.Therapeutic intervention based on protein prenylation and associated modificationsStructure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsStudying a complex tumor: potential and pitfalls.Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.Rational modification of a candidate cancer drug for use against Chagas diseaseThe protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines.Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor.Design, synthesis and anti-tobacco mosaic virus (TMV) activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-yl)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives.Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome.Study on Molecular Recognition betweenEuphorbia FactorL713283 andβ-Tubulin via Molecular Simulation Methods
P2860
Q24569706-F16CA170-BEBE-49E2-A04D-1D158F430683Q27653956-08C97092-3D5F-451F-947C-B97AE75B86AEQ27671538-F2E483DB-3296-45A4-B12C-4AA0A2A4E82EQ27680918-D6D6D423-1808-4CFF-BB7B-66C806BED8C4Q33603523-2507BD63-50B9-4D31-8891-E152F4FE056FQ33671341-20239381-C6F4-4041-975C-7A769B9F5DBCQ33843725-5DB73A8E-73BF-4DE8-B237-741E1207A309Q33879398-964EA01A-43DE-49EA-834C-726B99875D27Q33943379-B96B1F00-CD20-430C-A5C4-B4B34D78F783Q34609385-8297A542-0895-46A4-A1CC-D6BC28327C55Q35929525-3584E799-1506-4F4D-AFAB-9C3CD5D4D7B4Q36181770-3F632556-58D9-42C9-BB40-01395DC0B560Q37274008-02B90410-14D3-4C1F-A4FC-1BBA31E8CF80Q40652703-F9DB83DE-0FD0-4478-AA2F-7E7868EE430BQ41578013-AC822CCB-BF59-4BFA-B377-113360D7C7B5Q41903406-6E4A6F7F-AECF-48AD-B049-4970D51A1E34Q42041612-FEFF923C-D26F-461B-9799-31DA94A6E2D7Q42175330-78C87468-9212-4098-8FFB-DBB64309ADC7Q45231874-9046E581-430E-43D6-9118-2F475335668EQ47251070-12F7A7DB-6E20-4107-BF20-C48C2493EF9BQ59112203-3894CEF2-16AA-4CCC-B169-4BD7CD9C6D93
P2860
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structures of the anti ...... a mechanism of FTI selectivity
@ast
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en-gb
Crystal structures of the anti ...... a mechanism of FTI selectivity
@nl
type
label
Crystal structures of the anti ...... a mechanism of FTI selectivity
@ast
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en-gb
Crystal structures of the anti ...... a mechanism of FTI selectivity
@nl
prefLabel
Crystal structures of the anti ...... a mechanism of FTI selectivity
@ast
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en-gb
Crystal structures of the anti ...... a mechanism of FTI selectivity
@nl
P356
P1433
P1476
Crystal structures of the anti ...... a mechanism of FTI selectivity
@en
P2093
Lorena S Beese
T Scott Reid
P304
P356
10.1021/BI049723B
P407
P577
2004-06-08T00:00:00Z