HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions
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Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1The restriction factors of human immunodeficiency virusHIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceMagic angle spinning NMR of virusesNMR structures of membrane proteins in phospholipid bilayersVpu and BST2: Still Not There Yet?Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion releaseDifferential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance.Tetherin Antagonism by HIV-1 Group M Nef Proteins.Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain.Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir.Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee hostBST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.Impact of histidine residues on the transmembrane helices of viroporins.Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity.Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.Simian-Human immunodeficiency viruses expressing chimeric subtype B/C Vpu proteins demonstrate the importance of the amino terminal and transmembrane domains in the rate of CD4(+) T cell loss in macaques.Vpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.Genetic characterization of natural variants of Vpu from HIV-1 infected individuals from Northern India and their impact on virus release and cell death.Vpu binds directly to tetherin and displaces it from nascent virions.The secret life of viral entry glycoproteins: moonlighting in immune evasion.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.Viral miniproteinsMembrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral AssemblyStructural Basis for the Antiviral Activity of BST-2/Tetherin and Its Viral AntagonismSerine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.Relating structure and function of viral membrane-spanning miniproteinsMolecular dynamics simulation in virus research.Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses.A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2.The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release.Host restriction factors in retroviral infection: promises in virus-host interaction.Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression.The structural biology of HIV-1: mechanistic and therapeutic insightsImproving HIV proteome annotation: new features of BioAfrica HIV Proteomics Resource.A comparative mutational analysis of HIV-1 Vpu subtypes B and C for the identification of determinants required to counteract BST-2/Tetherin and enhance viral egress.Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic ApproachesFunctional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions.
P2860
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P2860
HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions
description
2012 nî lūn-bûn
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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@ast
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en-gb
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@nl
type
label
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@ast
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en-gb
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@nl
altLabel
HIV-1 Vpu Protein Antagonizes ...... edded Helix-Helix Interactions
@en
prefLabel
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@ast
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en-gb
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@nl
P2093
P2860
P3181
P356
P1476
HIV-1 Vpu protein antagonizes ...... edded helix-helix interactions
@en
P2093
Andrey Tokarev
Autumn Ruiz
Edward B Stephens
Jason Munguia
John Guatelli
Mark Skasko
Stanley J Opella
P2860
P3181
P356
10.1074/JBC.M111.296772
P407
P577
2012-01-02T00:00:00Z