CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
about
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage responseThe helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cellsThe Role of PCNA Posttranslational Modifications in Translesion SynthesisThe Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like ModifiersFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressGenomic instability in cancer.A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteinsGain of function in CDKN1CA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseKSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTLDegradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL4Cdt2: master coordinator of cell cycle progression and genome stabilityProliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.Parkin regulates translesion DNA synthesis in response to UV radiationRAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNARad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.The unusual UBZ domain of Saccharomyces cerevisiae polymerase ηTwo replication fork maintenance pathways fuse inverted repeats to rearrange chromosomesRepair of naturally occurring mismatches can induce mutations in flanking DNA.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Tumour suppressor ING1b maintains genomic stability upon replication stress.The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCIMolecular chaperone Hsp90 regulates REV1-mediated mutagenesis.Regulation of the Fanconi anemia pathway by a SUMO-like delivery networkMechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseN-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cellsBub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis.Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.Protein monoubiquitylation: targets and diverse functionsY-family DNA polymerases and their role in tolerance of cellular DNA damage.
P2860
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P248
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P2860
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@ast
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en-gb
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@nl
type
label
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@ast
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en-gb
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@nl
prefLabel
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@ast
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en-gb
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@nl
P2860
P921
P3181
P1433
P1476
CRL4(Cdt2) E3 ubiquitin ligase ...... mote translesion DNA synthesis
@en
P2093
Amir A Jazaeri
Kenta Terai
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2009.12.018
P407
P577
2010-01-01T00:00:00Z