3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins
about
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner earOncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesisBRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responsesSerine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction.Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathyPDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activityInduced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion.A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway.Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways.SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartanTGF-beta-dependent and -independent roles of STRAP in cancer.The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.Integration of phosphatidylinositol 3-kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression.Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity.NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions.Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity.Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development.
P2860
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P2860
3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@ast
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en-gb
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@nl
type
label
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@ast
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en-gb
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@nl
prefLabel
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@ast
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en-gb
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@nl
P2093
P2860
P356
P1476
3-Phosphoinositide-dependent P ...... interaction with Smad proteins
@en
P2093
Haiyoung Jung
Hyun-A Seong
Hyunjung Ha
Kyong-Tai Kim
P2860
P304
P356
10.1074/JBC.M609279200
P407
P577
2007-04-20T00:00:00Z