Characterization of the human mitochondrial methionyl-tRNA synthetase
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Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetaseYeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase.Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humansBrucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for BrucellosisNSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met)Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferaseNative tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAsUrea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutationThe human mitochondrial tRNAMet: structure/function relationship of a unique modification in the decoding of unconventional codons.Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation system.tRNA Modification and Genetic Code Variations in Animal Mitochondria.Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNAMet.Chimeric human mitochondrial PheRS exhibits editing activity to discriminate nonprotein amino acids.Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA.Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss.A disease-causing point mutation in human mitochondrial tRNAMet results in tRNA misfolding leading to defects in translational initiation and elongation.Identity elements for the aminoacylation of metazoan mitochondrial tRNA(Arg) have been widely conserved throughout evolution and ensure the fidelity of the AGR codon reassignment.Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria.Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.A homology model for Clostridium difficile methionyl tRNA synthetase: active site analysis and docking interactions.Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system.Structural characterization of free-state and product-state Mycobacterium tuberculosis methionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism.methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate_R-HSA-379726
P2860
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P2860
Characterization of the human mitochondrial methionyl-tRNA synthetase
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Characterization of the human mitochondrial methionyl-tRNA synthetase
@ast
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en-gb
Characterization of the human mitochondrial methionyl-tRNA synthetase
@nl
type
label
Characterization of the human mitochondrial methionyl-tRNA synthetase
@ast
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en-gb
Characterization of the human mitochondrial methionyl-tRNA synthetase
@nl
prefLabel
Characterization of the human mitochondrial methionyl-tRNA synthetase
@ast
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en-gb
Characterization of the human mitochondrial methionyl-tRNA synthetase
@nl
P2093
P921
P3181
P356
P1433
P1476
Characterization of the human mitochondrial methionyl-tRNA synthetase
@en
P2093
Achim Heck
Angela C Spencer
Kimitsuna Watanabe
Linda L Spremulli
Nono Takeuchi
P304
P3181
P356
10.1021/BI049639W
P407
P577
2004-08-03T00:00:00Z