Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I
about
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporterABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-IAssociation of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cellsATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol effluxPurification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol effluxDifferential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsMammalian P4-ATPases and ABC transporters and their role in phospholipid transportThe interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipidsEctopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosisSPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporterIdentification and characterization of rodent ABCA1 in isolated type II pneumocytesPhosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-IAlpha1-syntrophin modulates turnover of ABCA1.APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans.A novel model of cholesterol efflux from lipid-loaded cellsBinding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol exportThe ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease.Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degenerationATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.Regulation and mechanisms of macrophage cholesterol effluxA PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.Characteristics and functional relevance of apolipoprotein-A1 and cholesterol binding in mammary gland tissues and epithelial cellsABCA1 and nascent HDL biogenesisAcrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry.High density lipoprotein structure-function and role in reverse cholesterol transport.Regulation of ABCA1 functions by signaling pathwaysHigh-density lipoproteins: multifunctional vanguards of the cardiovascular system.ABCA1 and atherosclerosis.Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages.Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporterLXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration.Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux.Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population.ABC transporters, atherosclerosis and inflammation.Lipid outward translocation by ABC proteins.Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth.
P2860
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P2860
Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Naturally occurring mutations ...... action with apolipoprotein A-I
@ast
Naturally occurring mutations ...... action with apolipoprotein A-I
@en
Naturally occurring mutations ...... action with apolipoprotein A-I
@en-gb
Naturally occurring mutations ...... action with apolipoprotein A-I
@nl
type
label
Naturally occurring mutations ...... action with apolipoprotein A-I
@ast
Naturally occurring mutations ...... action with apolipoprotein A-I
@en
Naturally occurring mutations ...... action with apolipoprotein A-I
@en-gb
Naturally occurring mutations ...... action with apolipoprotein A-I
@nl
prefLabel
Naturally occurring mutations ...... action with apolipoprotein A-I
@ast
Naturally occurring mutations ...... action with apolipoprotein A-I
@en
Naturally occurring mutations ...... action with apolipoprotein A-I
@en-gb
Naturally occurring mutations ...... action with apolipoprotein A-I
@nl
P2093
P356
P1476
Naturally occurring mutations ...... action with apolipoprotein A-I
@en
P2093
Andrea L Morris
Armando J Mendez
Jeongmi S Rhee
Lorna P Andersson
Mason W Freeman
Michael L Fitzgerald
P304
P356
10.1074/JBC.M204996200
P407
P577
2002-09-06T00:00:00Z