Grb7-SH2 domain dimerisation is affected by a single point mutation
about
Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulationGrb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferationWater-refined solution structure of the human Grb7-SH2 domain in complex with the erbB2 receptor peptide pY1139Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand.The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation.Receptor protein-tyrosine phosphatase α regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility.Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents.Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain.Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1Dimerization in the Grb7 protein.Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene.Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?Grb7 protein RA domain oligomerization.
P2860
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P2860
Grb7-SH2 domain dimerisation is affected by a single point mutation
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Grb7-SH2 domain dimerisation is affected by a single point mutation
@ast
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en-gb
Grb7-SH2 domain dimerisation is affected by a single point mutation
@nl
type
label
Grb7-SH2 domain dimerisation is affected by a single point mutation
@ast
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en-gb
Grb7-SH2 domain dimerisation is affected by a single point mutation
@nl
prefLabel
Grb7-SH2 domain dimerisation is affected by a single point mutation
@ast
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en-gb
Grb7-SH2 domain dimerisation is affected by a single point mutation
@nl
P2093
P3181
P1476
Grb7-SH2 domain dimerisation is affected by a single point mutation
@en
P2093
Corrine J Porter
Jackie A Wilce
Matthew C J Wilce
Peter Leedman
P2888
P304
P3181
P356
10.1007/S00249-005-0480-1
P407
P577
2005-07-01T00:00:00Z
P6179
1026119145