Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewCardiac troponin mutations and restrictive cardiomyopathyA troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponinCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeInterplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failureSelective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavageClinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathyA mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillationRestricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisisAdaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth diseaseTroponin T core structure and the regulatory NH2-terminal variable regionEffects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin CTroponin T isoforms and posttranscriptional modifications: Evolution, regulation and functionExpression and functional properties of four slow skeletal troponin T isoforms in rat musclesDecreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin THypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation.Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation.Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.Human slow troponin T (TNNT1) pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults.Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approachMechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies.Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.Structure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptationCa²⁺ sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion.Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle.Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affairChronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodelingThe N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filamentThe functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Quantitative and evolutionary biology of alternative splicing: how changing the mix of alternative transcripts affects phenotypic plasticity and reaction norms.Troponin T nuclear localization and its role in aging skeletal muscleThe functional significance of the last 5 residues of the C-terminus of cardiac troponin I.A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.Inherited cardiomyopathies caused by troponin mutations.Pre-mRNA mis-splicing of sarcomeric genes in heart failure.Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.Role of myofibril-inducing RNA in cardiac TnT expression in developing Mexican axolotl.
P2860
Q21129229-D1BCC3BC-37BA-40B5-B909-D35C8D1007BDQ21328674-62D2906C-ADFD-417A-8E07-027620CB73CEQ24301265-156757C7-A520-422E-A652-69F6BC85BC38Q28066435-06D7C91E-53AB-463B-9BE5-EC4A6E067C3BQ28261234-7FACC19E-1026-4FD2-BAB5-2A4213903584Q28264199-CE39E217-E4EE-422C-BC2F-0E1B23F143D3Q28268628-7E161787-EA54-4764-9C90-A085A83BAA3CQ28271478-5D436596-44F1-4C7E-B802-B73504D2BF74Q28283976-D2673F33-0D79-46ED-88C5-E8DDA3395F1BQ28285189-8E09E4C2-B5CC-4007-85C2-489C57E4B689Q28285624-CAE16993-5AB5-4413-9B9F-BC6897C0AB25Q28287686-24D94614-8F25-4FD1-A71F-2C35A3366156Q28296309-B3F92A84-545F-4810-A1D6-1CD91C9544AAQ28566485-C6E505AD-8B9B-4C56-B790-8F4CA470D3DFQ30333375-3D021CDB-1BB3-4CC9-A3A7-E200F16C73BDQ33580919-88835DE0-F119-4609-892D-1C63812A33CBQ34107285-792BEEC9-AB6C-4338-8A0D-13A33B7E7092Q34248530-D9483D40-30C9-46BF-802B-C5D5724A0F30Q34608346-36ED4E7D-DE42-43CB-B697-BD4DE78D1F09Q34974513-ECBF9CEB-122C-447B-ABE4-AD77C8B9C11AQ35063399-CFE5D841-1B0A-463B-9499-D68E39F24C34Q35172648-013EB1B5-426B-4910-A204-DC7BC59B6A0CQ35311290-E4D52719-1014-4511-AF22-A223827BFAF2Q35336277-65A1AD1F-6A37-44C6-9CE5-D5CA050A109CQ35395931-B3326FA2-FA0B-4992-B609-38C9651C527AQ35633591-F81756EA-AAC0-4E8E-BA80-3F9EBE094623Q35679277-1E0028EC-A162-4ACA-885F-38AB831835F9Q36114673-49B8D0BD-543D-4B7E-9B4E-7CD5AB9550E6Q36207947-CB712EE5-AAD3-4C0A-AB5E-0D16C7F9509CQ36347849-2876FBA5-55D3-4920-8957-C1F184D2B237Q36593277-B2175545-2AC0-41E4-81C2-99939640F538Q36605975-AA0A1B34-921A-442F-AEC1-463FB441079EQ36670157-B7488F77-06DA-4561-8A91-DE3E3C3A420DQ36984498-864017AE-DFE6-46EB-BDBD-3B6453B9622EQ37254027-26B98D1D-25E8-408A-9BEF-EE2CDAD142BDQ37259559-1560F9A5-39EB-4665-909F-8AE0D53F8FA2Q38101039-1D756CBF-D0C5-4F21-8C38-415DF9E9F053Q39003222-D2CC3778-07BC-44BB-8A7E-CE2FC223F6C0Q41949346-1344E25D-A7FA-4603-8FA2-8C6C76BD9D02Q41949902-4D0503A4-33F4-4025-B711-AE4D65D59C7C
P2860
Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@ast
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en-gb
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@nl
type
label
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@ast
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en-gb
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@nl
prefLabel
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@ast
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en-gb
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@nl
P2093
P3181
P356
P1476
Cardiac troponin T isoforms af ...... oponin T isoforms in the heart
@en
P2093
Aldrin V Gomes
Georgianna Guzman
James D Potter
Jiaju Zhao
P304
P3181
P356
10.1074/JBC.M204118200
P407
P577
2002-09-20T00:00:00Z