CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
about
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerizationAdaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stressLoss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformationsReelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deploymentSmall-molecule agonists of mammalian Diaphanous-related (mDia) formins reveal an effective glioblastoma anti-invasion strategy.Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulumRHO binding to FAM65A regulates Golgi reorientation during cell migrationExceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutationsProtein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis.PDCD10 gene mutations in multiple cerebral cavernous malformationsPDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer.Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.Orientation and function of the nuclear-centrosomal axis during cell migration.A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).Crystallization and preliminary crystallographic studies of CCM3 in complex with the C-terminal domain of MST4.MST-4 and TRAF-6 expression in the peripheral blood mononuclear cells of patients with Graves' disease and its significance.Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zoneApicobasal polarity of brain endothelial cells.The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and PlasticityCCM3 Mutations Are Associated with Early-Onset Cerebral Hemorrhage and Multiple Meningiomas.Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.Introduction to cerebral cavernous malformation: a brief review.Cerebral cavernous malformation proteins at a glance.STRIPAK complexes: structure, biological function, and involvement in human diseases.Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Germinal center kinases in immune regulation.Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management.SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations.MicroRNA-103 suppresses tumor cell proliferation by targeting PDCD10 in prostate cancer.The cerebral cavernous malformation 3 gene is necessary for senescence induction.Silencing of STRN4 suppresses the malignant characteristics of cancer cells.Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.
P2860
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P2860
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@ast
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@en
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@nl
type
label
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@ast
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@en
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@nl
prefLabel
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@ast
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@en
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@nl
P2093
P50
P921
P356
P1476
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation
@en
P2093
Celia Pombo
María Fraile
P304
P356
10.1242/JCS.061341
P407
P577
2010-03-23T00:00:00Z