A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
about
The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenanceA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyProtein requirements for sister telomere association in human cellsGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsA quantitative telomeric chromatin isolation protocol identifies different telomeric statesIn vivo stoichiometry of shelterin componentsTelomere protection by mammalian Pot1 requires interaction with Tpp1POT1 association with TRF2 regulates telomere lengthCharacterization of the DNA binding specificity of Shelterin complexesTelomere dysfunction and cell survival: roles for distinct TIN2-containing complexesFinding the end: recruitment of telomerase to telomeresTelomere protection by TPP1 is mediated by POT1a and POT1bA balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytesTelomere biology: Rationale for diagnostics and therapeutics in cancerMultiple facets of TPP1 in telomere maintenanceFemtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Switching human telomerase on and off with hPOT1 protein in vitroGenetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulationFunctional interaction between telomere protein TPP1 and telomeraseThe TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityCell biology of disease: Telomeropathies: an emerging spectrum disorderTranscriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factorsPOT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationGeneration and characterization of telomere length maintenance in tankyrase 2-deficient mice.POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.Human telomerase: biogenesis, trafficking, recruitment, and activation.Persistent telomere cohesion triggers a prolonged anaphase.TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres.Telomere protection by TPP1/POT1 requires tethering to TIN2Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stabilityAlterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protectionTetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint.Telomere maintenance through spatial control of telomeric proteinsArabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.Distinct functions of POT1 at telomeres.Functional dissection of human and mouse POT1 proteins.
P2860
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P248
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P2860
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A dynamic molecular link betwe ...... chromosome end protector TRF2
@ast
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en-gb
A dynamic molecular link betwe ...... chromosome end protector TRF2
@nl
type
label
A dynamic molecular link betwe ...... chromosome end protector TRF2
@ast
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en-gb
A dynamic molecular link betwe ...... chromosome end protector TRF2
@nl
prefLabel
A dynamic molecular link betwe ...... chromosome end protector TRF2
@ast
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en-gb
A dynamic molecular link betwe ...... chromosome end protector TRF2
@nl
P921
P3181
P1433
P1476
A dynamic molecular link betwe ...... chromosome end protector TRF2
@en
P2093
Benjamin R Houghtaling
Leanora Cuttonaro
P304
P3181
P356
10.1016/J.CUB.2004.08.052
P407
P577
2004-09-21T00:00:00Z