The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesMitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxiaUnderstanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular modelsOxidative stress and the homeodynamics of iron metabolismIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesThe first cellular models based on frataxin missense mutations that reproduce spontaneously the defects associated with Friedreich ataxiaLimitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screenIron redistribution as a therapeutic strategy for treating diseases of localized iron accumulation.Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolismMice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.Iron-sulfur cluster biogenesis and human diseaseOver-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulationCharacterization of mitochondrial ferritin-deficient mice.Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.The power plant of the cell is also a smithy: the emerging role of mitochondria in cellular iron homeostasis.Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxiaThe emerging role of iron dyshomeostasis in the mitochondrial decay of aging.Frataxin: a protein in search for a function.Animal and cellular models of Friedreich ataxia.Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.Iron and Neurodegeneration: Is Ferritinophagy the Link?Frataxin silencing inactivates mitochondrial Complex I in NSC34 motoneuronal cells and alters glutathione homeostasisAssembly of the iron-binding protein frataxin in Saccharomyces cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level.Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells.Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors.
P2860
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P2860
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The effects of frataxin silenc ...... f human mitochondrial ferritin
@ast
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en
The effects of frataxin silenc ...... f human mitochondrial ferritin
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The effects of frataxin silenc ...... f human mitochondrial ferritin
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type
label
The effects of frataxin silenc ...... f human mitochondrial ferritin
@ast
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en-gb
The effects of frataxin silenc ...... f human mitochondrial ferritin
@nl
prefLabel
The effects of frataxin silenc ...... f human mitochondrial ferritin
@ast
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en-gb
The effects of frataxin silenc ...... f human mitochondrial ferritin
@nl
P2093
P50
P921
P1476
The effects of frataxin silenc ...... f human mitochondrial ferritin
@en
P2093
Emiliano Cocco
Manuela Derosas
Marcella Corrado
Maura Poli
P356
10.1016/J.BBADIS.2007.11.006
P407
P577
2008-02-01T00:00:00Z