Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
about
Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesisRegulation of cellular iron metabolismHuman iron-sulfur cluster assembly, cellular iron homeostasis, and diseaseSpliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisIron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster deliveryThe role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseasesEmerging critical roles of Fe-S clusters in DNA replication and repair.The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activityIron–Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei : Molecular Basis of Iron–Sulfur Cluster Coordination and Relevance for Parasite InfectivityMitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins.Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletionRecent advances in the understanding of myelodysplastic syndromes with ring sideroblasts.A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.The physiological functions of iron regulatory proteins in iron homeostasis - an update.Heme metabolism and erythropoiesis.Special delivery: distributing iron in the cytosol of mammalian cells.Erythropoiesis and iron sulfur cluster biogenesis.Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.Role of heme in cardiovascular physiology and disease.Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease.Cellular and mitochondrial iron homeostasis in vertebratesMonothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasisBoth human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesisSynthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.Mammalian iron metabolism and its control by iron regulatory proteinsNuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell deathA novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD).Out of balance--systemic iron homeostasis in iron-related disordersMonothiol glutaredoxins can bind linear [Fe3S4]+ and [Fe4S4]2+ clusters in addition to [Fe2S2]2+ clusters: spectroscopic characterization and functional implications.Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscleIron regulatory protein-1 protects against mitoferrin-1-deficient porphyria.Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.Iron-dependent functions of mitochondria--relation to neurodegeneration.Iron and erythropoiesis: a dual relationship.Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes.How I manage patients with atypical microcytic anaemia.Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes.
P2860
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P2860
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@ast
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en-gb
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@nl
type
label
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@ast
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en-gb
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@nl
prefLabel
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@ast
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en-gb
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@nl
P2093
P2860
P3181
P356
P1476
Glutaredoxin 5 deficiency caus ...... ic iron in human erythroblasts
@en
P2093
Danilo Ortillo
Gennadiy Kovtunovych
John Tisdale
Manik C Ghosh
Naoya Uchida
Suh Young Jeong
Tracey A Rouault
P2860
P304
P3181
P356
10.1172/JCI40372
P407
P577
2010-05-01T00:00:00Z