Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
about
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosisThe KEN box: an APC recognition signal distinct from the D box targeted by Cdh1A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41Distinct cell cycle-dependent roles for dynactin and dynein at centrosomesMultisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-boxCdk1, Plks, Auroras, and Neks: the mitotic bodyguardsTINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrestMolecular cloning and cell-cycle-dependent expression of a novel NIMA (never-in-mitosis in Aspergillus nidulans)-related protein kinase (TpNrk) in Tetrahymena cellsNIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesCharacterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse CochleaNek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatmentNek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos.Nek2 is a novel regulator of B cell development and immunological response.Role of NEK2A in human cancer and its therapeutic potentials.Nek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple‑negative breast cancer cells.Targeting NEK2 as a promising therapeutic approach for cancer treatment.Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteinsAn essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites.Local depletion of DNA methylation identifies a repressive p53 regulatory region in the NEK2 promoter.Premature chromatin condensation upon accumulation of NIMA.Identification of potential key genes associated with glioblastoma based on the gene expression profileNek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer.The G(2) checkpoint is maintained by redundant pathways.Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration.The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.Chromosomal instability and acquired drug resistance in multiple myeloma.Mitotic nuclear pore complex segregation involves Nup2 in Aspergillus nidulans.Prognostic value of NEK2 overexpression in digestive system cancers: a meta-analysis and systematic review
P2860
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P2860
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@ast
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en-gb
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@nl
type
label
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@ast
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en-gb
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@nl
prefLabel
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@ast
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en-gb
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@nl
P2093
P3181
P1476
Cell cycle-dependent expressio ...... ulator of Aspergillus nidulans
@en
P2093
P304
P3181
P407
P50
P577
1994-06-01T00:00:00Z