The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
about
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptorEnhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactomeSHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expressionIdentification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptorGastrointestinal stromal tumor and its targeted therapeutics.Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase functionInhibition of cytokines and JAK-STAT activation by distinct signaling pathways.c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling.Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction.Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts.Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression.SHP2 interacts with p-KITPhosphorylation of SHP2 by SFKsGRB2 is indirectly recruited to p-KIT through SHP2
P2860
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P2860
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@ast
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en-gb
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@nl
type
label
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@ast
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en-gb
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@nl
prefLabel
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@ast
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en-gb
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@nl
P2093
P1476
The ubiquitously expressed Syp ...... nd Grb2 in hematopoietic cells
@en
P2093
Broxmeyer HE
Marshall MS
P304
25206-25211
P407
P577
1994-10-01T00:00:00Z