Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein
about
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthaseNADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.NO formation by neuronal NO-synthase can be controlled by ultrafast electron injection from a nanotrigger.Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transferStructural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain.Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthaseMechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.Neutralizing a surface charge on the FMN subdomain increases the activity of neuronal nitric-oxide synthase by enhancing the oxygen reactivity of the enzyme heme-nitric oxide complexCharge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.Primary steps of the Na+-translocating NADH:ubiquinone oxidoreductase catalytic cycle resolved by the ultrafast freeze-quench approach.Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.
P2860
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P2860
Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@ast
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en-gb
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@nl
type
label
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@ast
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en-gb
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@nl
prefLabel
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@ast
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en-gb
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@nl
P2093
P356
P1433
P1476
Role of Asp1393 in catalysis, ...... ation of the nNOS flavoprotein
@en
P2093
David W Konas
Dennis J Stuehr
Manisha Sharma
Naoki Takaya
P304
P356
10.1021/BI061011T
P407
P577
2006-10-17T00:00:00Z