Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionThe Werner syndrome protein: linking the replication checkpoint response to genome stabilityRoles of Werner syndrome protein in protection of genome integritySirtuin 1 and sirtuin 3: physiological modulators of metabolismSIRT1 as a therapeutic target in inflammaging of the pulmonary diseaseSIRTain regulators of premature senescence and accelerated agingSirtuins in Cancer: a Balancing Act between Genome Stability and MetabolismSirtuins, metabolism, and DNA repairSirtuins in epigenetic regulationSirtuin-dependent epigenetic regulation in the maintenance of genome integritySIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammalsp53 Acetylation: Regulation and ConsequencesSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsNuclear DNA damage signalling to mitochondria in ageingEmerging Roles of SIRT1 in Cancer Drug ResistanceAcetylation of WRN protein regulates its stability by inhibiting ubiquitination.WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin.Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localizationIdentifying Human SIRT1 Substrates by Integrating Heterogeneous Information from Various Sources.Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.The impact of acetylation and deacetylation on the p53 pathway.FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage responseSIRT1 contributes to telomere maintenance and augments global homologous recombination.SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.Sirtuins and DNA damage repair: SIRT7 comes to play.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresKAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining RepairProtein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stabilitySIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells.Stem cell aging in adult progeria.Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.Sirtuin regulation in aging and injuryReplication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathwayHuman SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation.Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateauSIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cellsSIRT1, is it a tumor promoter or tumor suppressor?SIRT2 directs the replication stress response through CDK9 deacetylation.
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P2860
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@ast
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en-gb
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@nl
type
label
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@ast
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en-gb
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@nl
prefLabel
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@ast
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en-gb
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@nl
P2093
P2860
P921
P3181
P356
P1476
Regulation of WRN protein cell ...... y SIRT1-mediated deacetylation
@en
P2093
Alex Casta
David Orren
Enerlyn Lozada
Jianyuan Luo
Qingyuan Ge
Susan Kane
P2860
P304
P3181
P356
10.1074/JBC.M709707200
P407
P577
2008-03-21T00:00:00Z