A stapled BID BH3 helix directly binds and activates BAX
about
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolMembrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerizationBH3 domains other than Bim and Bid can directly activate Bax/BakBimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosisThe Bcl-2 apoptotic switch in cancer development and therapyIdentifying druggable disease-modifying gene productsBH3 mimetics to improve cancer therapy; mechanisms and examplesRegulation of Bim in Health and DiseaseThe role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyondA new view of the lethal apoptotic poreBAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial poreGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsSolution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 CapsidBAX activation is initiated at a novel interaction siteThe MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerEvidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAXRational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 InhibitorsStructural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 DomainDiscovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein ACasp8p41 generated by HIV protease kills CD4 T cells through direct Bak activationBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisCharge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulationBax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranesHydrocarbon-stapled peptides: principles, practice, and progressDual role of proapoptotic BAD in insulin secretion and beta cell survivalChemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targetingApplication of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Direct Activation of Bax Protein for Cancer TherapyConstraining cyclic peptides to mimic protein structure motifs.The use of therapeutic peptides to target and to kill cancer cells.A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1Conformation of BCL-XL upon Membrane IntegrationA competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survivalThe N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process.Emerging Bcl-2 inhibitors for the treatment of cancer.Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability.Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells
P2860
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P248
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P2860
A stapled BID BH3 helix directly binds and activates BAX
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A stapled BID BH3 helix directly binds and activates BAX
@ast
A stapled BID BH3 helix directly binds and activates BAX
@en
A stapled BID BH3 helix directly binds and activates BAX
@en-gb
A stapled BID BH3 helix directly binds and activates BAX
@nl
type
label
A stapled BID BH3 helix directly binds and activates BAX
@ast
A stapled BID BH3 helix directly binds and activates BAX
@en
A stapled BID BH3 helix directly binds and activates BAX
@en-gb
A stapled BID BH3 helix directly binds and activates BAX
@nl
prefLabel
A stapled BID BH3 helix directly binds and activates BAX
@ast
A stapled BID BH3 helix directly binds and activates BAX
@en
A stapled BID BH3 helix directly binds and activates BAX
@en-gb
A stapled BID BH3 helix directly binds and activates BAX
@nl
P2093
P921
P1433
P1476
A stapled BID BH3 helix directly binds and activates BAX
@en
P2093
Eric Smith
Gregory L Verdine
Jill Fisher
Joel Morash
Kenneth Pitter
Kyoung Joon Oh
Loren D Walensky
Scott Barbuto
Stanley J Korsmeyer
P304
P356
10.1016/J.MOLCEL.2006.08.020
P407
P577
2006-10-20T00:00:00Z