Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis
about
Mitochondria-associated membranes as hubs for neurodegenerationThe Function of Autophagy in Neurodegenerative DiseasesAutophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSRecent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative DiseasesLoss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbancesProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity.Sigma-1 receptor chaperones in neurodegenerative and psychiatric disordersA genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde traffickingSubcellular localization of the sigma-1 receptor in retinal neurons - an electron microscopy study.Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALSNeuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury.Anatomy and function of cholinergic C bouton inputs to motor neurons.The sigma-1 receptor: a regulator of cancer cell electrical plasticity?Studying neurodegenerative diseases in culture models.Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis.Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease.Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection.Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling.Sigma 1 Receptor and Ion Channel Dynamics in Cancer.Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial StructureThe SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis.Cellular Signature of SIL1 Depletion: Disease Pathogenesis due to Alterations in Protein Composition Beyond the ER Machinery.Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa.The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.Proteostasis disturbance in amyotrophic lateral sclerosis.Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS.The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis.In-depth phenotyping of lymphoblastoid cells suggests selective cellular vulnerability in Marinesco-Sjögren syndrome.Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease.Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.Reply: Is SIGMAR1 a confirmed FTD/MND gene?Mitochondrial-Associated Membranes in Parkinson's Disease.Sigma-1 Receptor in Motoneuron Disease.Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration.Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration.
P2860
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P2860
Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@ast
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en-gb
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@nl
type
label
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@ast
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en-gb
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@nl
prefLabel
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@ast
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en-gb
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@nl
P2093
P356
P1476
Altered localization, abnormal ...... amyotrophic lateral sclerosis
@en
P2093
E Bushuven
M Deschauer
M Schnizler
P304
P356
10.1093/HMG/DDT008
P407
P577
2013-01-11T00:00:00Z