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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signalingActivity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activitymTOR: from growth signal integration to cancer, diabetes and ageingIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlmTOR: a potential therapeutic target in osteoarthritis?The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses14-3-3 proteins--an updateAssociation of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growthRegulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growthAkt1 governs breast cancer progression in vivo.p27Kip1 localization depends on the tumor suppressor protein tuberin.Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway.14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling.REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β.The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits.Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.Lipid posttranslational modifications. Farnesyl transferase inhibitors.OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma.The tuberous sclerosis complex genes in tumor development.Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia.Negative regulation of the RalGAP complex by 14-3-3.14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity.The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA.Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.mTOR signaling and its roles in normal and abnormal brain development.Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.The 14-3-3 protein translates the NA+,K+-ATPase {alpha}1-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis.Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of TSC2 by 14-3-3 binding
@ast
Regulation of TSC2 by 14-3-3 binding
@en
Regulation of TSC2 by 14-3-3 binding
@en-gb
Regulation of TSC2 by 14-3-3 binding
@nl
type
label
Regulation of TSC2 by 14-3-3 binding
@ast
Regulation of TSC2 by 14-3-3 binding
@en
Regulation of TSC2 by 14-3-3 binding
@en-gb
Regulation of TSC2 by 14-3-3 binding
@nl
prefLabel
Regulation of TSC2 by 14-3-3 binding
@ast
Regulation of TSC2 by 14-3-3 binding
@en
Regulation of TSC2 by 14-3-3 binding
@en-gb
Regulation of TSC2 by 14-3-3 binding
@nl
P2093
P2860
P3181
P356
P1476
Regulation of TSC2 by 14-3-3 binding
@en
P2093
Kun-Liang Guan
Raymond Yeung
P2860
P304
P3181
P356
10.1074/JBC.C200510200
P407
P577
2002-11-22T00:00:00Z