Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor
about
Differential activation of CC chemokine receptors by AOP-RANTESRegulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and traffickingIdentification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalizationMonocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2Modeling cell gradient sensing and migration in competing chemoattractant fieldsDeletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responsesTargeting CXCR1/CXCR2 receptor antagonism in malignant melanomaPhosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzymeShort tail with skin lesion phenotype occurs in transgenic mice with keratin-14 promoter-directed expression of mutant CXCR2.Chemoattractant receptor cross-desensitization.Chemokine receptor trafficking and viral replication.Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17).Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5Chemokine receptor internalization and intracellular trafficking.Modeling the role of homologous receptor desensitization in cell gradient sensingInhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis.RhoB plays an essential role in CXCR2 sorting decisions.The functional significance behind expressing two IL-8 receptor types on PMN.Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration.Differential regulation of CXCR2 trafficking by Rab GTPases.Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases.Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis.CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.Comparative analysis of high-affinity ligand binding and G protein coupling of the human CXCR1 chemokine receptor and of a CXCR1-Galpha fusion protein after heterologous production in baculovirus-infected insect cells.The chemokine KC regulates HGF-stimulated epithelial cell morphogenesis.G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.Role of clathrin-mediated endocytosis in CXCR2 sequestration, resensitization, and signal transduction.Multiple signaling pathways of human interleukin-8 receptor A. Independent regulation by phosphorylation.Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression.Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors.Inhibition of signal termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste signal termination.Cellular assays of chemokine receptor activation.G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions.
P2860
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P2860
Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Ligand-induced desensitization ...... erminal domain of the receptor
@ast
Ligand-induced desensitization ...... erminal domain of the receptor
@en
Ligand-induced desensitization ...... erminal domain of the receptor
@en-gb
Ligand-induced desensitization ...... erminal domain of the receptor
@nl
type
label
Ligand-induced desensitization ...... erminal domain of the receptor
@ast
Ligand-induced desensitization ...... erminal domain of the receptor
@en
Ligand-induced desensitization ...... erminal domain of the receptor
@en-gb
Ligand-induced desensitization ...... erminal domain of the receptor
@nl
prefLabel
Ligand-induced desensitization ...... erminal domain of the receptor
@ast
Ligand-induced desensitization ...... erminal domain of the receptor
@en
Ligand-induced desensitization ...... erminal domain of the receptor
@en-gb
Ligand-induced desensitization ...... erminal domain of the receptor
@nl
P2093
P2860
P921
P356
P1476
Ligand-induced desensitization ...... erminal domain of the receptor
@en
P2093
P2860
P304
P356
10.1074/JBC.272.13.8207
P407
P577
1997-03-28T00:00:00Z