Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2 - Wikidata - awgldk - TriplyDB

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

http://www.wikidata.org/entity/Q24310889

about

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease Apo E structure determines VLDL clearance and atherosclerosis risk in mice.Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability.Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.Knock-in of Enhanced Green Fluorescent Protein or/and Human Fibroblast Growth Factor 2 Gene into β-Casein Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein.The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.The role of apolipoprotein E in Alzheimer's disease.Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity.Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis.Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia.Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse A practical approach to using mice in atherosclerosis research.APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.Protein mediators of sterol transport across intestinal brush border membrane.Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations.Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein.Simultaneous analysis of dendritic spine density, morphology and excitatory glutamate receptors during neuron maturation in vitro by quantitative immunocytochemistry Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo.ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency Apolipoprotein E2 accentuates postprandial inflammation and diet-induced obesity to promote hyperinsulinemia in mice.ApoE isoform-dependent deficits in extinction of contextual fear conditioning.

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Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

http://www.wikidata.org/entity/Q24310889

description

1998 nî lūn-bûn

@nan

1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հուլիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

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Journal of Clinical Investigation

P1476

Type III hyperlipoproteinemia ...... f mouse Apoe with human Apoe*2

@en

P2093

H Mezdour

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N Maeda

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P M Sullivan

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S H Quarfordt

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P2860

Fat transport in lipoproteins--an integrated approach to mechanisms and disorders

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

Pre-beta-very low density lipoproteins as precursors of beta-very low density lipoproteins. A model for the pathogenesis of familial dysbetalipoproteinemia (type III hyperlipoproteinemia)

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.

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130-5

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scholarly article

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10.1172/JCI2673

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P433

1

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P478

102

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1998-07-01T00:00:00Z

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9649566

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P921

atherosclerosis

cholesterol homeostasis

Apolipoprotein E

P932

509074

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