The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling - Wikidata - awgldk - TriplyDB

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling

The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling

http://www.wikidata.org/entity/Q24310890

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Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1 The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.Integrin alpha5beta1 function is regulated by XGIPC/kermit2 mediated endocytosis during Xenopus laevis gastrulation.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.Integrin targeted therapeutics.Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies.Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells Prognostic implications of tumoral expression of insulin like growth factors 1 and 2 in patients with non-small-cell lung cancer.Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway.The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche Sclerostin's role in bone's adaptive response to mechanical loading.Cross-talk between the insulin-like growth factor (IGF) axis and membrane integrins to regulate cell physiology.Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3.Anabolic effects of IGF-1 signaling on the skeleton.Cell-based assays for IGF-I bioactivity measurement: overview, limitations and current trends.Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.Insulin-like growth factor axis targeting in cancer and tumour angiogenesis - the missing link.Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1.Distribution of insulin receptor and insulin-like growth factor-1 receptor in the digital laminae of mixed-breed ponies: an immunohistochemical study.Dual action of bacteriocin PLNC8 αβ through inhibition of Porphyromonas gingivalis infection and promotion of cell proliferation.Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.MicroRNA-Mediated Regulation of ITGB3 and CHL1 Is Implicated in SSRI Action.Secreted Phospholipase A2 Type IIA (sPLA2-IIA) Activates Integrins in an Allosteric Manner.Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis.

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The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling

http://www.wikidata.org/entity/Q24310890

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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JBC.M109.013201

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Journal of Biological Chemistry

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The direct binding of insulin- ...... is involved in IGF-1 signaling

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Chun-Yi Wu

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Fu-Tong Liu

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Jun Saegusa

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Katsuaki Ieguchi

http://www.w3.org/2001/XMLSchema#string

Kit S Lam

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Satoshi Yamaji

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Yoko K Takada

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the extracellular segment of integrin alpha Vbeta3

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

Integrins: bidirectional, allosteric signaling machines

RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.

Integrins and Src: dynamic duo of adhesion signaling.

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.

Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma.

Stage-specific expression of integrin alphaVbeta3 in neuroblastic tumors.

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24106-14

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scholarly article

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10.1074/JBC.M109.013201

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36

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284

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Yoshikazu Takada

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2009-09-04T00:00:00Z

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19578119

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Insulin like growth factor 1

Insulin like growth factor 1 receptor

alphav-beta3 integrin-IGF-1-IGF1R complex

Integrin subunit alpha V

Integrin subunit beta 3

P932

2782004

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