Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation
about
Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome AssemblyLiver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteinsUSP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor {alpha} by the proteasome.Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice.The emerging role of the COP9 signalosome in cancer.JAB1/CSN5: a new player in cell cycle control and cancerGenetic regulators of large-scale transcriptional signatures in cancer.Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.Inhibitory SMADs: potential regulators of ovarian functionDevelopmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis.Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.Targeting Jab1/CSN5 in nasopharyngeal carcinomaTHE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosisThe transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo.Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity.Transforming growth factor-beta signaling and ubiquitinators in cancer.CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progressionTo (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modificationsPorcine JAB1 significantly enhances apoptosis induced by staurosporine.COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-βSmad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.Roles of COP9 signalosome in cancer.SMAD7: a timer of tumor progression targeting TGF-β signaling.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation.RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.Signaling pathways regulating cartilage growth plate formation and activity.Roles of Multifunctional COP9 Signalosome Complex in Cell Fate and Implications for Drug Discovery.Regulation of TGF-β Family Signaling by Inhibitory Smads.Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1.Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets.Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein.Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
P2860
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P2860
Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation
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name
Jab1/CSN5, a component of the ...... and promoting its degradation
@ast
Jab1/CSN5, a component of the ...... and promoting its degradation
@en
Jab1/CSN5, a component of the ...... and promoting its degradation
@en-gb
Jab1/CSN5, a component of the ...... and promoting its degradation
@nl
type
label
Jab1/CSN5, a component of the ...... and promoting its degradation
@ast
Jab1/CSN5, a component of the ...... and promoting its degradation
@en
Jab1/CSN5, a component of the ...... and promoting its degradation
@en-gb
Jab1/CSN5, a component of the ...... and promoting its degradation
@nl
prefLabel
Jab1/CSN5, a component of the ...... and promoting its degradation
@ast
Jab1/CSN5, a component of the ...... and promoting its degradation
@en
Jab1/CSN5, a component of the ...... and promoting its degradation
@en-gb
Jab1/CSN5, a component of the ...... and promoting its degradation
@nl
P2093
P2860
P1476
Jab1/CSN5, a component of the ...... and promoting its degradation
@en
P2093
Angelina Felici
Byung-Chul Kim
Dug Keun Lee
Ho-Jae Lee
James G McNally
Sae Ra Lee
Seok Hee Park
Seong-Jin Kim
Tatiana S Karpova
P2860
P304
P356
10.1128/MCB.24.6.2251-2262.2004
P407
P577
2004-03-01T00:00:00Z