The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration
about
Role of mitochondrial lipids in guiding fission and fusionF-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development.The BAR Domain Superfamily Proteins from Subcellular Structures to Human DiseasesF-BAR domain proteins: Families and function.The proposed functions of membrane curvatures mediated by the BAR domain superfamily proteins.The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor α with the small GTPase Rac.A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesissrGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity.Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerHeterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensorThe molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase DThe mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 associationSPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegansPhosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of actionProtective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized ReceptorOligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cellsHGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancerFER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance.Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.Overexpression of Cucumber Phospholipase D alpha Gene (CsPLDα) in Tobacco Enhanced Salinity Stress Tolerance by Regulating Na+-K+ Balance and Lipid Peroxidation.Phosphoinositide-binding interface proteins involved in shaping cell membranes.Potassium channels in cell cycle and cell proliferation.Regulation of mitochondrial morphology by lipids.Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins.Linking up at the BAR: Oligomerization and F-BAR protein function.Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression.The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasivenessSecond international conference on F-BAR proteins: October 1-3, 2009 at Rånäs Slott, Sweden.Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems.FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer.
P2860
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P2860
The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration
description
2009 nî lūn-bûn
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2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The tyrosine kinase Fer is a d ...... that regulates cell migration
@ast
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en-gb
The tyrosine kinase Fer is a d ...... that regulates cell migration
@nl
type
label
The tyrosine kinase Fer is a d ...... that regulates cell migration
@ast
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en-gb
The tyrosine kinase Fer is a d ...... that regulates cell migration
@nl
prefLabel
The tyrosine kinase Fer is a d ...... that regulates cell migration
@ast
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en-gb
The tyrosine kinase Fer is a d ...... that regulates cell migration
@nl
P2093
P1433
P1476
The tyrosine kinase Fer is a d ...... that regulates cell migration
@en
P2093
Junya Hasegawa
Kazuya Tsujita
Tadaomi Takenawa
Toshiki Itoh
Yasunori Kanaho
P356
10.1126/SCISIGNAL.2000393
P407
P577
2009-01-01T00:00:00Z