Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
about
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediatesBLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repairHuman DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesHuman Dna2 is a nuclear and mitochondrial DNA maintenance proteinStudies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replicationDNA resection in eukaryotes: deciding how to fix the breakOkazaki fragment maturation: nucleases take centre stageThe MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.Dna2 exhibits a unique strand end-dependent helicase function.Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity.Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation.Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integritySgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsXenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMProcessing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition.Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae.Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.Reconstitution of eukaryotic lagging strand DNA replication.Mitochondrial helicases and mitochondrial genome maintenanceTelomeres: structures in need of unwinding.Modulation of the Pyrococcus abyssi NucS endonuclease activity by replication clamp at functional and structural levels.DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cellsIdentification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels.MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication.Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repairBorrowing nuclear DNA helicases to protect mitochondrial DNA.Biochemical studies of the Saccharomyces cerevisiae Mph1 helicase on junction-containing DNA structuresYet another job for Dna2: Checkpoint activation.Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability.Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.Nucleases: diversity of structure, function and mechanism.Mitochondrial DNA maintenance: an appraisal.DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?Dna2 initiates resection at clean DNA double-strand breaks.
P2860
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P2860
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
description
2006 nî lūn-bûn
@nan
2006 թուականին հրատարակուած գիտական յօդուած
@hyw
2006 թվականին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@ast
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en-gb
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@nl
type
label
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@ast
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en-gb
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@nl
prefLabel
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@ast
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en-gb
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@nl
P2093
P2860
P3181
P356
P1476
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
@en
P2093
Do-Hyung Kim
Gi-Hyuck Ryu
Hee-Dai Kim
Jeong-Hoon Kim
Jerard Hurwitz
Yeon-Soo Seo
P2860
P304
P3181
P356
10.1093/NAR/GKL102
P407
P577
2006-01-01T00:00:00Z