WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes
about
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαRecruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7AStructure and control of the actin regulatory WAVE complexEndosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromerEndosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.WASH inhibits autophagy through suppression of Beclin 1 ubiquitinationRegulation of WASH-dependent actin polymerization and protein trafficking by ubiquitinationRole of the Retromer Complex in Neurodegenerative DiseasesThe retromer complex - endosomal protein recycling and beyondCapping protein regulators fine-tune actin assembly dynamicsUnder lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processesFunction and regulation of the endosomal fusion and fission machineriesPhosphoinositides in the mammalian endo-lysosomal networkActin polymerization controls the organization of WASH domains at the surface of endosomesThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.ER contact sites define the position and timing of endosome fissionInteractions of Isolated C-terminal Fragments of Neural Wiskott-Aldrich Syndrome Protein (N-WASP) with Actin and Arp2/3 ComplexControl of polarized assembly of actin filaments in cell motilityRetromer-mediated endosomal protein sorting: all WASHed up!Cinderella story: PI4P goes from precursor to key signaling moleculeRecent advances in retromer biologyDendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell primingWASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector functionWASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytesUSP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental DisorderDysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complexMutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagyWash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAMLWASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.Phase transitions of multivalent proteins can promote clustering of membrane receptorsNew mechanisms and functions of actin nucleationNuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.Physiology and pathology of endosome-to-Golgi retrograde sorting.
P2860
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P248
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P2860
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
WASH and WAVE actin regulators ...... structurally related complexes
@ast
WASH and WAVE actin regulators ...... structurally related complexes
@en
WASH and WAVE actin regulators ...... structurally related complexes
@en-gb
WASH and WAVE actin regulators ...... structurally related complexes
@nl
type
label
WASH and WAVE actin regulators ...... structurally related complexes
@ast
WASH and WAVE actin regulators ...... structurally related complexes
@en
WASH and WAVE actin regulators ...... structurally related complexes
@en-gb
WASH and WAVE actin regulators ...... structurally related complexes
@nl
prefLabel
WASH and WAVE actin regulators ...... structurally related complexes
@ast
WASH and WAVE actin regulators ...... structurally related complexes
@en
WASH and WAVE actin regulators ...... structurally related complexes
@en-gb
WASH and WAVE actin regulators ...... structurally related complexes
@nl
P2093
P2860
P921
P3181
P356
P1476
WASH and WAVE actin regulators ...... structurally related complexes
@en
P2093
Daniel D Billadeau
Junko Umetani
Michael K Rosen
Timothy S Gomez
Zoltan Metlagel
P2860
P304
10442-10447
P3181
P356
10.1073/PNAS.0913293107
P407
P577
2010-05-24T00:00:00Z