Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells
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Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathwayNSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathwayBCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cellsThe docking protein HEF1 is an apoptotic mediator at focal adhesion sitesAND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphologySplice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signalingNSP-Cas protein structures reveal a promiscuous interaction module in cell signalingThe serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundleProtein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell linesTemporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomicsNSP-CAS Protein Complexes: Emerging Signaling Modules in CancerFulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complexAssociation of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistanceA novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1ALoss of AND-34/BCAR3 expression in mice results in rupture of the adult lensBreast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas)The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein CasSynergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomesBreast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane rufflingBCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signalingPathways to tamoxifen resistance.Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer.Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation.The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells.Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity.BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinibNanometer-scale mapping and single-molecule detection with color-coded nanoparticle probes.Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancerRaising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survivalAND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern.CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer.Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells.BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells.Evaluation of the ability of adjuvant tamoxifen-benefit gene signatures to predict outcome of hormone-naive estrogen receptor-positive breast cancer patients treated with tamoxifen in the advanced setting.
P2860
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P2860
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Identification of BCAR3 by a r ...... e of human breast cancer cells
@ast
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en-gb
Identification of BCAR3 by a r ...... e of human breast cancer cells
@nl
type
label
Identification of BCAR3 by a r ...... e of human breast cancer cells
@ast
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en-gb
Identification of BCAR3 by a r ...... e of human breast cancer cells
@nl
prefLabel
Identification of BCAR3 by a r ...... e of human breast cancer cells
@ast
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en-gb
Identification of BCAR3 by a r ...... e of human breast cancer cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
Identification of BCAR3 by a r ...... e of human breast cancer cells
@en
P2093
L C Dorssers
P J van der Spek
T L van Agthoven
T van Agthoven
P2860
P304
P3181
P356
10.1093/EMBOJ/17.10.2799
P407
P577
1998-05-15T00:00:00Z