Proapoptotic function of the retinoblastoma tumor suppressor protein
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cyclep38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisRibosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repairRB1: a prototype tumor suppressor and an enigmaMolecular mechanisms underlying RB protein functionUnderstanding pRb: toward the necessary development of targeted treatments for retinoblastomaEmerging links between E2F control and mitochondrial functionTranscriptional control of stem cell fate by E2Fs and pocket proteinsPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylationArabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair.The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in ArabidopsisArabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.Targeting tumor suppressor networks for cancer therapeutics.E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaksIdentification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancersDNA damage signals through differentially modified E2F1 molecules to induce apoptosis.Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.Targeting Rb inactivation in cancers by synthetic lethality.Role of Drosophila retinoblastoma protein instability element in cell growth and proliferationMutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.Tumour suppressor genes in chemotherapeutic drug response.RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation.Radiation-induced microRNA-622 causes radioresistance in colorectal cancer cells by down-regulating RbThe requirement for cyclin D function in tumor maintenance.The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage.Cooperative activation of tissue-specific genes by pRB and E2F1.pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila.The retinoblastoma protein induces apoptosis directly at the mitochondriaRB goes mitochondrialEZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway.Regional signals in the planarian body guide stem cell fate in the presence of genomic instability.Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival.RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1.p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation.pRb, a local chromatin organizer with global possibilities.
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P2860
Proapoptotic function of the retinoblastoma tumor suppressor protein
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Proapoptotic function of the retinoblastoma tumor suppressor protein
@ast
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en-gb
Proapoptotic function of the retinoblastoma tumor suppressor protein
@nl
type
label
Proapoptotic function of the retinoblastoma tumor suppressor protein
@ast
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en-gb
Proapoptotic function of the retinoblastoma tumor suppressor protein
@nl
prefLabel
Proapoptotic function of the retinoblastoma tumor suppressor protein
@ast
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en-gb
Proapoptotic function of the retinoblastoma tumor suppressor protein
@nl
P2093
P2860
P921
P1433
P1476
Proapoptotic function of the retinoblastoma tumor suppressor protein
@en
P2093
Alberto Gulino
Alessandra Ianari
Edoardo Alesse
Eliezer Calo
Elisabetta Ferretti
Isabella Screpanti
Jacqueline A Lees
Kevin Haigis
Tiziana Natale
P2860
P304
P356
10.1016/J.CCR.2009.01.026
P407
P577
2009-03-03T00:00:00Z