Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart
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Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit geneL-type calcium channels: the low downDifferent voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variantsTranscript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit.Multiple modulation pathways of calcium channel activity by a beta subunit. Direct evidence of beta subunit participation in membrane trafficking of the alpha1C subunit.Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failureEffects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia.The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels.Glutamate substitution in repeat IV alters divalent and monovalent cation permeation in the heart Ca2+ channel.Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of L-type calcium channels.Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function.A gene for episodic ataxia/myokymia maps to chromosome 12p13.Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha1C subunit.CACNA1C (Cav1.2) in the pathophysiology of psychiatric diseaseRegulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha).Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea.L-type calcium channel current up-regulation by chronic stress is associated with increased alpha(1c) subunit expression in rat ventricular myocytes.L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.The role of region IVS5 of the human cardiac calcium channel in establishing inactivated channel conformation: use-dependent block by benzothiazepines.The relationship of stress and blood pressure effectors.Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain.Cardiac L-type calcium channel beta-subunits expressed in human heart have differential effects on single channel characteristics.Molecular determinant for run-down of L-type Ca2+ channels localized in the carboxyl terminus of the 1C subunit.A sequence in the carboxy-terminus of the alpha(1C) subunit important for targeting, conductance and open probability of L-type Ca(2+) channels.Clotrimazole inhibits the recombinant human cardiac L-type Ca2+ channel alpha 1C subunit.Modulation of recombinant human cardiac L-type Ca2+ channel alpha1C subunits by redox agents and hypoxia.Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.The N terminus of the cardiac L-type Ca(2+) channel alpha(1C) subunit. The initial segment is ubiquitous and crucial for protein kinase C modulation, but is not directly phosphorylated.Regulation of Ca-sensitive inactivation of a 1-type Ca2+ channel by specific domains of beta subunits.The G. L. Brown Prize Lecture. Hypoxic regulation of ion channel function and expression.Effects of 2,3-butanedione monoxime (BDM) on calcium channels expressed in Xenopus oocytes.Architecture of Ca(2+) channel pore-lining segments revealed by covalent modification of substituted cysteines.Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship
P2860
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P2860
Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
name
Cloning, chromosomal localizat ...... hannel from normal human heart
@ast
Cloning, chromosomal localizat ...... hannel from normal human heart
@en
Cloning, chromosomal localizat ...... hannel from normal human heart
@en-gb
Cloning, chromosomal localizat ...... hannel from normal human heart
@nl
type
label
Cloning, chromosomal localizat ...... hannel from normal human heart
@ast
Cloning, chromosomal localizat ...... hannel from normal human heart
@en
Cloning, chromosomal localizat ...... hannel from normal human heart
@en-gb
Cloning, chromosomal localizat ...... hannel from normal human heart
@nl
prefLabel
Cloning, chromosomal localizat ...... hannel from normal human heart
@ast
Cloning, chromosomal localizat ...... hannel from normal human heart
@en
Cloning, chromosomal localizat ...... hannel from normal human heart
@en-gb
Cloning, chromosomal localizat ...... hannel from normal human heart
@nl
P2093
P2860
P356
P1476
Cloning, chromosomal localizat ...... hannel from normal human heart
@en
P2093
D O Weghuis
M Wakamori
U Klöckner
P2860
P304
P356
10.1073/PNAS.90.13.6228
P407
P577
1993-07-01T00:00:00Z