PTPN14 interacts with and negatively regulates the oncogenic function of YAP
about
PTPN14 is required for the density-dependent control of YAP1Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativityThe Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and BeyondThe two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentTargeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer TherapyYAP and TAZ: a nexus for Hippo signaling and beyondThe Hippo signaling pathway in stem cell biology and cancerPTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic functionThe tyrosine phosphatase PTPN14 is a negative regulator of YAP activity.Molecular profiling and computational network analysis of TAZ-mediated mammary tumorigenesis identifies actionable therapeutic targets.The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovaryGenetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch.Disease implications of the Hippo/YAP pathway.A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN.Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitisProteomic approaches to the study of papillomavirus-host interactions.Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformationHigh-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation.AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol.Integration of mechanical and chemical signals by YAP and TAZ transcription coactivatorsSplice variant insertions in the C-terminus impairs YAP's transactivation domain.Regulation of the Hippo pathway and implications for anticancer drug development.ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition.The Hippo signaling pathway provides novel anti-cancer drug targets.The Hippo pathway: regulators and regulations.The expanding family of FERM proteins.The Hippo signal transduction network in skeletal and cardiac muscle.Genetic alterations of protein tyrosine phosphatases in human cancers.The mammalian Hippo pathway: regulation and function of YAP1 and TAZ.The regulation and function of YAP transcription co-activator.Tyrosine phosphorylation of WW proteins.Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.c-Abl antagonizes the YAP oncogenic function.Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer.The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7.VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
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PTPN14 interacts with and negatively regulates the oncogenic function of YAP
description
2013 nî lūn-bûn
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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2013年の論文
@ja
2013年学术文章
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2013年学术文章
@zh-cn
2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@ast
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en-gb
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@nl
type
label
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@ast
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en-gb
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@nl
prefLabel
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@ast
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en-gb
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@nl
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PTPN14 interacts with and negatively regulates the oncogenic function of YAP
@en
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C D Morrison
I H Gelman
K E Wilson
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10.1038/ONC.2012.147
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2013-03-07T00:00:00Z
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P6179
1039640337