NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)
about
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradationImplications of NQO1 in cancer therapyKeep-ING balance: tumor suppression by epigenetic regulationQuinone reductase acts as a redox switch of the 20S yeast proteasome.NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorNAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome.NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest.Regulating the 20S proteasome ubiquitin-independent degradation pathway.GLAD4U: deriving and prioritizing gene lists from PubMed literatureSrc regulates the activity of the ING1 tumor suppressor.NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomasThe NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence.Patient outcome prediction using multiple biomarkers in human melanoma: A clinicopathological study of 118 casesNAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease.NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease.NQO1 inhibits proteasome-mediated degradation of HIF-1α.NAD(P)H: quinone oxidoreductase 1 and its potential protective role in cardiovascular diseases and related conditions.Regulation of p53 by ING family members in suppression of tumor initiation and progression.ING1 and ING2: multifaceted tumor suppressor genes.RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators.INGs are potential drug targets for cancer.The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells.Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system.The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients.Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function.Redox modulation of NQO1.Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).Tumor suppressor Ing1b facilitates DNA repair and prevents oxidative stress induced cell death.
P2860
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P2860
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@ast
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en-gb
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@nl
type
label
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@ast
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en-gb
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@nl
prefLabel
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@ast
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en-gb
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@nl
P2093
P2860
P356
P1433
P1476
NAD(P)H quinone oxidoreductase ...... e tumour suppressor p33(ING1b)
@en
P2093
Marco Garate
Ronald P C Wong
Yemin Wang
P2860
P304
P356
10.1038/EMBOR.2008.48
P407
P577
2008-06-01T00:00:00Z